菠萝蛋白酶：其机制、药理作用和潜在应用的综述,Food & Function

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菠萝蛋白酶：其机制、药理作用和潜在应用的综述
Food & Function ( IF 5.1 ) Pub Date : 2023-08-11 , DOI: 10.1039/d3fo01060k
Virender Kumar _{1,

2} , Bharti Mangla ₃ , Shamama Javed ₄ , Waquar Ahsan ₅ , Pankaj Kumar ₃ , Vandana Garg ₁ , Harish Dureja ₁

Affiliation

利用植物源补充剂来预防和治疗疾病因其巨大的潜力而早已得到认可。Ananas comosus，俗称菠萝，产生一组称为菠萝蛋白酶的酶，其中含有巯基部分。最近的研究表明，菠萝蛋白酶具有广泛的活性，包括抗炎、抗糖尿病、抗癌和抗风湿特性。这些特性使菠萝蛋白酶成为治疗各种疾病的有前途的候选药物。菠萝蛋白酶的抗炎活性已被证明可用于治疗骨关节炎、类风湿性关节炎和哮喘等炎症性疾病，而菠萝蛋白酶的抗癌活性是通过诱导细胞凋亡、抑制血管生成和增强机体的抗癌活性来实现的。免疫反应。菠萝蛋白酶的抗糖尿病特性是由于葡萄糖代谢的改善和胰岛素抵抗的减少。菠萝蛋白酶的治疗潜力已在大量临床前和临床研究中得到研究，迄今为止已获得多项专利。为了提高该分子的功效和安全性，正在开发各种制剂和递送系统，包括治疗口腔炎症的微囊形式和治疗癌症的脂质体制剂。新型药物递送系统和制剂的开发通过提高菠萝蛋白酶的生物利用度和稳定性，同时减少副作用，进一步提高了菠萝蛋白酶的治疗潜力。本综述旨在讨论菠萝蛋白酶的各种特性和治疗应用，以及其治疗各种疾病的可能作用机制。还涵盖了有关菠萝蛋白酶的最新专利和临床试验。

"点击查看英文标题和摘要"

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

The utilization of plant-derived supplements for disease prevention and treatment has long been recognized because of their remarkable potential. Ananas comosus, commonly known as pineapple, produces a group of enzymes called bromelain, which contains sulfhydryl moieties. Recent studies have shown that bromelain exhibits a wide range of activities, including anti-inflammatory, anti-diabetic, anti-cancer, and anti-rheumatic properties. These properties make bromelain a promising drug candidate for the treatment of various diseases. The anti-inflammatory activity of bromelain has been shown to be useful in treating inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and asthma, whereas the anti-cancer activity of bromelain is via induction of apoptosis, inhibition of angiogenesis, and enhancement of the body's immune response. The anti-diabetic property of bromelain is owing to the improvement in glucose metabolism and reduction in insulin resistance. The therapeutic potential of bromelain has been investigated in numerous preclinical and clinical studies and a number of patents have been granted to date. Various formulations and delivery systems are being developed in order to improve the efficacy and safety of this molecule, including the microencapsulated form to treat oral inflammatory conditions and liposomal formulations to treat cancer. The development of novel drug delivery systems and formulations has further ameliorated the therapeutic potential of bromelain by improving its bioavailability and stability, while reducing the side effects. This review intends to discuss various properties and therapeutic applications of bromelain, along with its possible mechanism of action in treating various diseases. Recent patents and clinical trials concerning bromelain have also been covered.

更新日期：2023-08-11

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