Iron-Mediated Domino Interrupted Iso-Nazarov/Dearomative (3 + 2)-Cycloaddition of Electrophilic Indoles,Organic Letters

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Iron-Mediated Domino Interrupted Iso-Nazarov/Dearomative (3 + 2)-Cycloaddition of Electrophilic Indoles
Organic Letters ( IF 4.9 ) Pub Date : 2016-10-04 00:00:00 , DOI: 10.1021/acs.orglett.6b02613
Anne-Sophie Marques ₁ , Vincent Coeffard ₁ , Isabelle Chataigner ₂ , Guillaume Vincent ₃ , Xavier Moreau ₁

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An efficient domino reaction combining different classes of pericyclic reactions leads to chiral complex polycyclic indoline-based architectures from achiral starting materials under mild conditions. This practical method is based on the ability of iron(III) chloride to promote both 4π electrocyclizations of 2,4-dienals and the C2–C3 umpolung of N-acetylindoles during the dearomative (3 + 2) cycloadditions.

中文翻译：

铁介导的多米诺中断Iso-Nazarov / Demoomative（3 + 2）-亲电子吲哚的环加成

结合不同类别的周环反应的有效多米诺反应可在温和条件下从非手性原料中获得基于手性复杂多环吲哚啉的结构。该实用方法基于氯化铁（III）在脱芳香性（3 + 2）环加成过程中促进2，4-二烯醛的4π电环化和N-乙酰吲哚的C2-C3活化的能力。

更新日期：2016-10-04

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