The salient features of zircon (ZrSiO₄) display their application potential in hard tissue replacements. However, the formation of ZrSiO₄ through synthetic approach at relatively low temperature requires the addition of mineralizers. Herein, titanium has been used as a mineralizer to promote the ZrSiO₄ formation and further a series of dual substitution of Tb³⁺/PO₄³⁻ have been undertaken to investigate their capability to accommodate at the tetragonal crystal lattice of ZrSiO₄. The rationale to substitute Tb³⁺/PO₄³⁻ is mainly based on tailoring the bioimaging capacity of ZrSiO₄ by hosting Tb³⁺ whereas the accommodation of PO₄³⁻ is due to its significance in forming a major component in inorganic bone mineral. The characterization studies revealed the dual occupancy of Tb³⁺/PO₄³⁻ at the crystal lattice of ZrSiO₄ until 10 mol%, beyond which the crystallization of TbPO₄ is noticed. Tb³⁺ substitution has induced a series of fascinating features in ZrSiO₄ namely the fluorescence in the visible region, computed tomography (CT) efficiency, paramagnetic response with T₂ magnetic resonance imaging (MRI) characteristics. Nevertheless, the crystallization of TbPO₄ as a secondary component signified a detrimental effect on the mechanical properties of ZrSiO₄. The in vitro tests performed on MG63 cell lines accomplished the biocompatibility features of Tb³⁺/PO₄³⁻ substituted ZrSiO₄.

_{锆石（ZrSiO 4} ）的显着特征显示了其在硬组织替代物中的应用潜力。然而，在较低温度下通过合成方法形成ZrSiO ₄需要添加矿化剂。在此，钛已被用作矿化剂以促进ZrSiO ₄的形成，并且进一步进行了一系列Tb ³⁺ /PO ₄ ³⁻的双重取代以研究它们适应ZrSiO ₄四方晶格的能力。替代Tb ³⁺ /PO ₄ ³⁻的基本原理主要是基于调整ZrSiO _{4的生物成像能力}通过容纳 Tb ³⁺而容纳 PO ₄ ³⁻是因为它在形成无机骨矿物质的主要成分方面具有重要意义。_{表征研究揭示了ZrSiO 4}晶格中Tb ³⁺ /PO ₄ ³⁻的双重占据直至10 mol%，超过此值时注意到TbPO ₄的结晶。Tb ^{3+取代在 ZrSiO} ₄中引入了一系列令人着迷的特征，即可见光区域的荧光、计算机断层扫描 (CT) 效率、T _{2的顺磁响应}磁共振成像（MRI）特征。_{然而，作为次要组分的TbPO 4}的结晶对ZrSiO ₄的机械性能产生不利影响。对MG63细胞系进行的体外测试实现了Tb ³⁺ /PO ₄ ³⁻取代的ZrSiO ₄的生物相容性特征。