Therapeutic drugs for human cardiovascular disease require specific carriers. Hydrogels have a porous structure, plasticity, and biocompatibility, and are ideal carriers for cardiovascular drugs. Moreover, for their intended functions, hydrogels also need to have high mechanical properties, self-healing properties, good pH-responsive performance, and other properties. Here, based on the interactions between multiple dynamic covalent bonds, we effectively synthesized hybrid hydrogels of carboxymethyl chitosan (C-CS), aldehyde-modified hyaluronic acid (OHA), polyvinyl alcohol (PVA), and boric acid (BA). The multiple covalent bonds reinforce each other, endowing the hydrogels with high mechanical properties, self-healing properties and pH responsiveness. In addition, the whole preparation process does not require crosslinking agents and the operation process is simple. The results show that the 5% PVA + C-CS + OHA + BA hydrogel has high mechanical properties (tensile stress 40.07 KPa; compressive stress 553.38 KPa), good self-healing performance (up to 92%) and excellent pH responsive performance. In addition, the hydrogel has high drug-loading capacity (117.54 mg/g) and sustained-release performance. In conclusion, this hybrid hydrogel can potentially be used as a drug carrier for clinical treatment.

人类心血管疾病的治疗药物需要特定的载体。水凝胶具有多孔结构、可塑性和生物相容性，是心血管药物的理想载体。此外，为了实现其预期功能，水凝胶还需要具有高机械性能、自修复性能、良好的pH响应性能等性能。在这里，基于多个动态共价键之间的相互作用，我们有效合成了羧甲基壳聚糖（C-CS）、醛改性透明质酸（OHA）、聚乙烯醇（PVA）和硼酸（BA）的杂化水凝胶。多个共价键相互增强，赋予水凝胶高机械性能、自修复性能和pH响应性。此外，整个制备过程不需要交联剂，操作过程简单。结果表明，5% PVA + C-CS + OHA + BA 水凝胶具有较高的机械性能（拉应力 40.07 KPa；压应力 553.38 KPa）、良好的自修复性能（高达 92%）和优异的 pH 响应性能。此外，该水凝胶还具有高载药量（117.54 mg/g）和缓释性能。总之，这种混合水凝胶有可能用作临床治疗的药物载体。54 mg/g）和缓释性能。总之，这种混合水凝胶有可能用作临床治疗的药物载体。54 mg/g）和缓释性能。总之，这种混合水凝胶有可能用作临床治疗的药物载体。