丙二醛作为过敏性疾病的潜在氧化应激标志物：最新进展,Molecules

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丙二醛作为过敏性疾病的潜在氧化应激标志物：最新进展
Molecules ( IF 4.2 ) Pub Date : 2023-08-09 , DOI: 10.3390/molecules28165979
Raffaele Cordiano ₁ , Mario Di Gioacchino _{2,

3} , Rocco Mangifesta ₂ , Claudia Panzera ₁ , Sebastiano Gangemi ₁ , Paola Lucia Minciullo ₁

Affiliation

丙二醛（MDA）是一种源自多不饱和脂肪酸过氧化的化合物。它已被用作生物标志物来测量受多种疾病影响的患者的各种生物样本中的氧化应激。我们工作的目的是提供 MDA 作为过敏相关疾病氧化应激标志物作用的最新概述。我们考虑了涉及受鼻炎、哮喘、荨麻疹和特应性皮炎影响的儿童和成人患者的研究。MDA 的测量是对不同类型的样品进行的。报告的数据强调了血清 MDA 在炎症性气道疾病中的作用。根据文献综述，通过 MDA 测定评估的哮喘患者的氧化应激状态在存在其他过敏性气道疾病的情况下似乎会恶化，并且与疾病的严重程度相关。这表明MDA可以作为监测疾病状态的合适标志物。然而，由于使用的样本不同以及缺乏对所检查患者的临床阶段的表型分析和描述，所考虑的研究存在一些局限性。在皮肤过敏性疾病中，由于研究规模较小以及样本和患者的异质性，MDA 的作用存在争议。

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Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseases. The aim of our work is to provide an updated overview of the role of MDA as a marker of oxidative stress in allergy-related diseases. We considered studies involving both paediatric and adult patients affected by rhinitis, asthma, urticaria and atopic dermatitis. The measurement of MDA was performed on different types of samples. The reported data highlight the role of serum MDA in inflammatory airway diseases. According to the literature review, the oxidative stress status in asthmatic patients, assessed via MDA determination, appears to worsen in the presence of other allergic airway diseases and in relation to the disease severity. This suggests that MDA can be a suitable marker for monitoring the disease status. However, there are several limitations in the considered studies due to the different samples used and the lack of phenotyping and description of the clinical period of patients examined. In cutaneous allergic diseases, the role of MDA is controversial because of the smallness of the studies and the heterogeneity of the samples and patients.

更新日期：2023-08-09

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