The studies on metal complexes as potential antifungals are of growing interest because they may be the answer to increasingly effective defense mechanisms. Herein we present two new copper(I) iodide or thiocyanide complexes with 2,9-dimethyl-1,10-phenanthroline (dmp) and diphenylphosphine derivative of 1-(4-methoxyphenyl)piperazine (4MP): [CuI(dmp)4MP] (1-4MP) and [CuNCS(dmp)4MP] (2-4MP) - their synthesis, as well as structural and spectroscopic characteristics. Interestingly, while 4MP and its oxide derivative (4MOP) show a very low or no activity against all tested Candida albicans strains (MIC₅₀ ≥ 200 μM against CAF2–1 - laboratory control strain, DSY1050 - mutant without transporters Cdr1, Cdr2, Mdr1; isogenic for CAF2–1, and fluconazole resistant clinical isolates), for 1-4MP and 2-4MP MIC₅₀ values were 0.4 μM, independently on the complex and strain tested. Determination of the viability of NHDF-Ad (Normal Adult Human Dermal Fibroblasts) cell line treated with 1-4MP and 2-4MP showed that for both complexes there was only a 20% reduction in the concentration range ¼ to 2 × MIC₅₀ and the 70% at 4 × MIC₅₀. Subsequently, the MLCT based luminescence of the complexes in aqueous media allowed to record the confocal micrographs of 1-4MP in the cells. The results show that it is situated most likely in the vacuoles (C. albicans) or lysosomes (NHDF-Ad).

关于金属配合物作为潜在抗真菌剂的研究越来越引起人们的兴趣，因为它们可能是日益有效的防御机制的答案。在此，我们提出了两种新的碘化亚铜或硫氰化铜与 2,9-二甲基-1,10-菲咯啉 (dmp) 和 1-(4-甲氧基苯基)哌嗪的二苯基膦衍生物 ( 4MP ) 的络合物：[CuI( dmp ) 4MP ] ( 1-4MP ) 和 [CuNCS(dmp) 4MP ] ( 2-4MP ) - 它们的合成，以及结构和光谱特征。有趣的是，虽然4MP及其氧化物衍生物 ( 4MOP ) 对所有测试的白色念珠菌菌株均表现出非常低的活性或没有活性（ 对 CAF2–1 - 实验室对照菌株、DSY1050 - 没有转运蛋白 Cdr1、Cdr2、Mdr1 的突变体， MIC ₅₀ ≥ 200 μM； CAF2-1 和氟康唑耐药临床分离株的同基因），1-4MP和2-4MP 的MIC ₅₀值为 0.4 μM，与测试的复合物和菌株无关。对用1-4MP和2-4MP处理的 NHDF-Ad（正常成人真皮成纤维细胞）细胞系的活力测定表明，两种复合物的浓度范围 1/4 至 2 × MIC ₅₀仅降低了 20%，并且4 × MIC ₅₀时为 70% 。随后，基于 MLCT 的复合物在水介质中的发光允许记录细胞中1-4MP的共焦显微照片。结果表明，它最有可能位于液泡（白色念珠菌）或溶酶体（NHDF-Ad）中。