Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases. Polarity, a key parameter of the microenvironment, is closely associated with many diseases and dysfunctions in the body. It is important to elucidate the relationship between the physiological activity of lipid droplets (LDs) and the polarity of the microenvironment. In this work, based on push-pull mechanism, a fluorescent probe ()-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop‑2-en-1-one (PPTH) with aggregation-induced emission (AIE) properties for the detection of polarity changes in cells was synthesized. PPTH not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

中文翻译：

---

一种脂滴靶向荧光探针，用于铁死亡、炎症和脂肪肝组织细胞极性检测

脂滴的异常积累和代谢可导致多种疾病。极性是微环境的关键参数，与体内许多疾病和功能障碍密切相关。阐明脂滴（LD）的生理活性与微环境极性之间的关系非常重要。本工作基于推拉机制，荧光探针()-3-(5-(4-(二苯氨基)苯基)噻吩-2-基)-1-(2-羟基苯基)prop-2-en-合成了具有聚集诱导发射（AIE）特性的 1-one（PPTH），用于检测细胞中的极性变化。 PPTH 不仅可以可视化铁死亡和炎症的细胞内极性波动，还可以区分正常肝组织和脂肪肝组织。