The two-electron oxygen reduction reaction in acid is highly attractive to produce H₂O₂, a commodity chemical vital in various industry and household scenarios, which is still hindered by the sluggish reaction kinetics. Herein, both density function theory calculation and in-situ characterization demonstrate that in dual-atom CoIn catalyst, O-affinitive In atom triggers the favorable and stable adsorption of hydroxyl, which effectively optimizes the adsorption of OOH on neighboring Co. As a result, the oxygen reduction on Co atoms shifts to two-electron pathway for efficient H₂O₂ production in acid. The H₂O₂ partial current density reaches 1.92 mA cm⁻² at 0.65 V in the rotating ring-disk electrode test, while the H₂O₂ production rate is as high as 9.68 mol g⁻¹ h⁻¹ in the three-phase flow cell. Additionally, the CoIn-N-C presents excellent stability during the long-term operation, verifying the practicability of the CoIn-N-C catalyst. This work provides inspiring insights into the rational design of active catalysts for H₂O₂ production and other catalytic systems.

酸中的双电子氧还原反应对于生产H ₂ O ₂非常有吸引力，H 2 O 2 是一种在各种工业和家庭场景中至关重要的商品化学品，但其仍然受到缓慢的反应动力学的阻碍。在此，密度函数理论计算和原位表征都表明，在双原子CoIn催化剂中，O-亲和In原子引发了羟基的有利且稳定的吸附，从而有效优化了OOH在邻近Co上的吸附。 Co原子上的氧还原转变为双电子途径，以在酸中高效生产H ₂ O ₂。旋转环盘电极测试中0.65 V时H ₂ O ₂部分电流密度达到1.92 mA cm ^-2 ，而三元循环中H ₂ O ₂产率高达9.68 mol g ^-1 h ^{-1 。}相流动池。此外，CoIn-NC在长期运行过程中表现出优异的稳定性，验证了CoIn-NC催化剂的实用性。这项工作为 H ₂ O ₂生产活性催化剂和其他催化系统的合理设计提供了启发性的见解。