Although the antitumor activities of 8-hydroxyquinoline complexes have been reported, their applications in the mitochondrial imaging and chemodynamic therapy of tumors have been rarely studied. In this work, we received a manganese complex: Mn(L)₂(DPPZ) (1-Mn), by using 5,7-dibromo-2-methyl-8-hydroxyquinoline (HL) as the active ligand together with dipyridophenazine (DPPZ) as the auxiliary ligand reacting with manganese chloride. It was found that 1-Mn had well antitumor activity on HepG-2 cells with IC₅₀ value of 7 ± 0.26 µM, which was accompanied by the generation of large amounts of ·OH via 1-Mn-mediated Fenton-like reaction of H₂O₂, thereby stimulating oxidative stress in the mitochondria and leading to cell death ultimately. In addition, confocal imaging showed that 1-Mn could be enriched in the mitochondria of HepG-2 cells and show blue fluorescence. Studies have shown that 1-Mn can be potentially used in the biomedical imaging and CDT anticancer drug.

尽管8-羟基喹啉复合物的抗肿瘤活性已有报道，但其在肿瘤线粒体成像和化学动力学治疗中的应用却很少被研究。在这项工作中，我们使用5,7-二溴-2-甲基-8-羟基喹啉（HL）作为活性配体与二吡啶吩嗪一起得到了锰配合物：Mn(L) ₂ (DPPZ) (1-Mn)。 DPPZ)作为辅助配体与氯化锰反应。结果发现1-Mn对HepG-2细胞具有良好的抗肿瘤活性，IC ₅₀值为7±0.26 µM，同时伴随着1-Mn介导的H的Fenton样反应产生大量·OH。₂氧₂，从而刺激线粒体中的氧化应激并最终导致细胞死亡。此外，共聚焦成像显示1-Mn可以富集在HepG-2细胞的线粒体中并呈现蓝色荧光。研究表明1-Mn在生物医学成像和CDT抗癌药物中具有潜在的应用前景。