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Tailoring the Swelling-Shrinkable Behavior of Hydrogels for Biomedical Applications
Advanced Science ( IF 14.3 ) Pub Date : 2023-08-06 , DOI: 10.1002/advs.202303326 Wenjun Feng 1 , Zhengke Wang 1
Advanced Science ( IF 14.3 ) Pub Date : 2023-08-06 , DOI: 10.1002/advs.202303326 Wenjun Feng 1 , Zhengke Wang 1
Affiliation
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Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with high swelling capacity have been widely applicated in full-thickness skin wound healing and tissue regeneration, and drug delivery. Nevertheless, in the fields of tissue adhesives and internal soft-tissue wound healing, and bioelectronics, non-swelling hydrogels play very important functions owing to their stable macroscopic dimension and physical performance in physiological environment. Moreover, the negative swelling behavior (i.e., shrinkage) of hydrogels can be exploited to drive noninvasive wound closure, and achieve resolution enhancement of hydrogel scaffolds. In addition, it can help push out the entrapped drugs, thus promote drug release. However, there still has not been a general review of the constructions and biomedical applications of hydrogels from the viewpoint of swelling-shrinkable properties. Therefore, this review summarizes the tactics employed so far in tailoring the swelling-shrinkable properties of hydrogels and their biomedical applications. And a relatively comprehensive understanding of the current progress and future challenge of the hydrogels with different swelling-shrinkable features is provided for potential clinical translations.
中文翻译：
为生物医学应用定制水凝胶的溶胀-收缩行为
具有定制溶胀收缩特性的水凝胶引起了许多生物医学领域的极大兴趣。例如，由于膨胀是血液和伤口挤出物吸收、营养物质和代谢物的转移以及药物扩散和释放的关键问题，因此具有高膨胀能力的水凝胶已广泛应用于全层皮肤伤口愈合和组织再生和药物输送。然而，在组织粘合剂和内部软组织伤口愈合以及生物电子学领域，非溶胀水凝胶由于其稳定的宏观尺寸和在生理环境中的物理性能而发挥着非常重要的作用。此外，可以利用水凝胶的负膨胀行为（即收缩）来驱动无创伤口闭合，并实现水凝胶支架的分辨率增强。此外，它还可以帮助推出截留的药物，从而促进药物释放。然而，目前还没有从溶胀收缩特性的角度对水凝胶的结构和生物医学应用进行全面的综述。因此，这篇综述总结了迄今为止在调整水凝胶的溶胀-收缩特性及其生物医学应用方面所采用的策略。并对具有不同溶胀收缩特性的水凝胶的当前进展和未来挑战有一个相对全面的了解，为潜在的临床转化提供了依据。
更新日期：2023-08-06
中文翻译：
为生物医学应用定制水凝胶的溶胀-收缩行为
具有定制溶胀收缩特性的水凝胶引起了许多生物医学领域的极大兴趣。例如，由于膨胀是血液和伤口挤出物吸收、营养物质和代谢物的转移以及药物扩散和释放的关键问题，因此具有高膨胀能力的水凝胶已广泛应用于全层皮肤伤口愈合和组织再生和药物输送。然而，在组织粘合剂和内部软组织伤口愈合以及生物电子学领域，非溶胀水凝胶由于其稳定的宏观尺寸和在生理环境中的物理性能而发挥着非常重要的作用。此外，可以利用水凝胶的负膨胀行为（即收缩）来驱动无创伤口闭合，并实现水凝胶支架的分辨率增强。此外，它还可以帮助推出截留的药物，从而促进药物释放。然而，目前还没有从溶胀收缩特性的角度对水凝胶的结构和生物医学应用进行全面的综述。因此，这篇综述总结了迄今为止在调整水凝胶的溶胀-收缩特性及其生物医学应用方面所采用的策略。并对具有不同溶胀收缩特性的水凝胶的当前进展和未来挑战有一个相对全面的了解，为潜在的临床转化提供了依据。
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