NuA4 is a highly conserved histone acetyltransferase complex that functions in transcription and DNA repair. Four groups have recently determined the structure of NuA4 from two different yeasts using cryo-EM, revealing important mechanistic details of its function and allowing a detailed comparison to the related SAGA complex.

中文翻译：

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NuA4 组蛋白乙酰转移酶：SAGA 主题的变体

NuA4 是一种高度保守的组蛋白乙酰转移酶复合物，在转录和 DNA 修复中发挥作用。最近，四个小组利用冷冻电镜确定了来自两种不同酵母的 NuA4 的结构，揭示了其功能的重要机制细节，并可以与相关的 SAGA 复合物进行详细比较。