The presence of anorexia in animals is the most well-known clinical symptom of T-2 toxin poisoning. T-2 toxin is the most characteristic type A toxin in the trichothecene mycotoxins. The consumption of T-2 toxin can cause anorexic response in mice, rats, rabbits, and other animals. In this review, the basic information of T-2 toxin, appetite regulation mechanism and the molecular mechanism of T-2 toxin-induced anorectic response in animals are presented and discussed. The objective of this overview is to describe the research progress of anorexia in animals produced by T-2 toxin. T-2 toxin mainly causes antifeedant reaction through four pathways: vagus nerve, gastrointestinal hormone, neurotransmitter and cytokine. This review aims to give an academic basis and useable reference for the prevention and treatment of clinical symptoms of anorexia in animals resulting from T-2 toxin.

动物厌食是 T-2 毒素中毒最著名的临床症状。T-2毒素是单端孢菌素真菌毒素中最具特征的A型毒素。食用T-2毒素可引起小鼠、大鼠、兔子和其他动物的厌食反应。本文对T-2毒素的基本信息、食欲调节机制以及T-2毒素引起动物厌食反应的分子机制进行了介绍和讨论。本综述的目的是描述T-2毒素引起的动物厌食症的研究进展。T-2毒素主要通过迷走神经、胃肠激素、神经递质和细胞因子四种途径引起拒食反应。该综述旨在为T-2毒素引起的动物厌食症临床症状的防治提供学术依据和参考。