Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H₂O₂ → ‧OH for tumoral therapy. Unfortunately, H₂O₂ is often taken from the limited endogenous supply of H₂O₂ in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H₂O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe³⁺-N ≡ C-Fe²⁺ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O₂, H₂O_2, and ‧OH from H₂O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

化学动力学疗法(CDT)利用芬顿或类芬顿反应，H ₂ O ₂  → ‧OH后产生有毒的‧OH进行肿瘤治疗。不幸的是，H ₂ O ₂通常取自癌细胞中有限的内源性H ₂ O _{2供应。提出了水氧化CoFe普鲁士蓝(CFPB)纳米框架，以从H 2} O提供持​​续的、无外部能量的自供给·OH以进行CDT和/或光热疗法(PTT)。出乎意料的是，由于通过所提出的质子诱导金属置换反应增加了 Fe ³⁺ -N ≡ C-Fe ²⁺组成，所制备的不具有近红外（NIR）吸收的 CFPB 纳米立方体转化为具有 NIR 吸收的 CFPB 纳米框架。 。令人惊讶的是，CFPB纳米立方体和纳米框架都可以从H 2 O自供应O ₂、H ₂ O ₂和·OH ，其中纳米框架在·OH_的产生方面表现出色。模拟分析表明 CFPB 催化水氧化、氧还原和类 Fenton 反应的活性位点是分离的。脂质体覆盖的 CFPB 纳米框架可用于雄性肿瘤小鼠治疗的可控水驱动 CDT。