<br>香豆素及其衍生物的抗抑郁作用：研究进展的批判性分析,European Journal of Pharmacology

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香豆素及其衍生物的抗抑郁作用：研究进展的批判性分析
European Journal of Pharmacology ( IF 4.2 ) Pub Date : 2023-08-04 , DOI: 10.1016/j.ejphar.2023.175958
Nneka Augustina Akwu ₁ , Makhotso Lekhooa ₂ , Dou Deqiang ₃ , Adeyemi Oladapo Aremu ₄

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香豆素及其衍生物是非类黄酮多酚，具有多种药理活性，包括抗抑郁作用。本研究系统地考察了香豆素及其衍生物的抗抑郁作用与药理学途径、与其他疾病的关联、毒性和文献计量分析等时间序列研究进展的关系。使用系统评价和荟萃分析的首选报告项目（PRISMA）以及涉及 Biblioshiny（Bibliometrix 分析的 Web 界面和 VOSviewer 软件分析工具）的 R 包来处理本综述。从建库到 2023 年 1 月 21 日，在 Scopus、Web of Science 和 PubMed 中进行了文献检索。香豆素、抑郁症、香豆素衍生物和治疗是使用的主要检索词，导致纳入了 46 篇符合条件的出版物。东莨菪素、补骨脂素、7-羟基香豆素、meranzin hydrate、蛇床子素、艾斯库列素/伞形酮是研究最多的具有抗抑郁作用的香豆素。香豆素及其衍生物具有抗抑郁作用，对单胺氧化酶-B （毛-B）抑制具有更强的亲和力，并且它们通过神经递质通路对毛的抑制作用已得到充分研究。然而，表观遗传修饰、神经内分泌、神经营养途径的研究不足。最近的研究集中在它们的抗抑郁作用上，这些作用针对细胞因子和纤维肌痛。肠道微生物组、大脑和抑郁症之间存在联系;Meranzin hydrate 通过重塑胃肠道系统发挥抗抑郁活性。我们确定，关于一些香豆素及其衍生物支持其抗抑郁作用的经验数据是有限的。同样，几种香豆素及其衍生物的安全剂量范围尚未完全确定。

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Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances

Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and their derivatives in relation to time series of research progress in the pharmacological pathways, association with other diseases, toxicity and bibliometric analysis. The review was approached using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) coupled with R package involving Biblioshiny, a web interface for Bibliometrix analysis and VOSviewer software analytic tools. Literature searches were conducted in Scopus, Web of Science, and PubMed from the inception through January 21, 2023. Coumarins, depression, coumarin derivatives and treatment were the main search terms used which resulted in the inclusion of 46 eligible publications. Scopoletin, psoralen, 7-hydroxycoumarin, meranzin hydrate, osthole, esculetin/umbelliferone were the most studied coumarins with antidepressant effects. Coumarins and their derivatives exerted antidepressant effects with a stronger affinity for monoamine oxidase-B (MAO-B) inhibition and, their inhibitory effect via neurotransmitter pathway on MAO is well-studied. However, epigenetic modification, neuroendocrine, neurotrophic pathways are understudied. Recent research focuses on their antidepressant effects which targeted cytokines and fibromyalgia. There is a link between the gut microbiome, the brain, and depression; meranzin hydrate exerts an antidepressant activity by remodelling the gastrointestinal system. We established that empirical data on some coumarins and their derivatives to support their antidepressant effects are limited. Likewise, the safe dose range for several coumarins and their derivatives is yet to be fully determined.

更新日期：2023-08-04

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