Fused nitrogen-containing heterocyclic compounds have been identified to display a prominent role in medicinal chemistry, biochemistry, and other streams of science. Countless derivatives of pyrazolo[1,5-a] pyridine have been investigated by researchers for their distinct pharmacological characterization. In this article, we have revealed and arranged the various routes of synthesis and therapeutic activities such as dopamine binding affinity, kinase inhibitory activity, and PDE inhibitors of pyrazolo[1,5- a]pyridine-containing compounds which have been explored till now. The remarkable outcomes obtained via in vitro as well as in vivo profile screening of this moiety and its derivatives lead this scaffold to be recognized to a greater extent and examined further for better results. This review will give medicinal chemists a flying-bird eye catch view of pyrazolo[1,5-a] pyridine derivatives which will help them to design and synthesize potential compounds bearing this moiety.

中文翻译：

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吡唑并[1,5-a]吡啶的合成和药理学探索：综合综述

稠合含氮杂环化合物已被确定在药物化学、生物化学和其他科学领域发挥着重要作用。研究人员已经研究了无数吡唑并[1,5-a]吡啶衍生物的独特药理学特征。在这篇文章中，我们揭示并整理了迄今为止已探索的含吡唑并[1,5-a]吡啶化合物的各种合成途径和治疗活性，例如多巴胺结合亲和力、激酶抑制活性和PDE抑制剂。通过对该部分及其衍生物的体外和体内概况筛选获得的显着结果使该支架得到更大程度的认可并进一步检查以获得更好的结果。这篇综述将为药物化学家提供吡唑并[1,5-a]吡啶衍生物的鸟瞰图，这将帮助他们设计和合成带有该部分的潜在化合物。