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Core/Shell-Structured Ag2Te/Ag2Se Quantum Dots for High-Resolution In Vivo Fluorescence Imaging in the Near Infrared IIb Region
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-08-02 , DOI: 10.1021/acsanm.3c02256 Kai Wang 1 , Ku-Han Deng 1 , Yi-Shen Tian 1 , Meng-Ying Sun 1 , Zi-li Yu 2 , Zhi-Quan Tian 1, 1, 3 , Zhi-Ling Zhang 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-08-02 , DOI: 10.1021/acsanm.3c02256 Kai Wang 1 , Ku-Han Deng 1 , Yi-Shen Tian 1 , Meng-Ying Sun 1 , Zi-li Yu 2 , Zhi-Quan Tian 1, 1, 3 , Zhi-Ling Zhang 1
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Fluorescence in the near infrared IIb window (NIR-IIb, 1500–1700 nm) shows higher signal-to-noise ratio, better space-time resolution, and deeper tissue penetration. However, materials with excellent fluorescence properties in the NIR-IIb region were rarely reported. Ag2Te quantum dots (QDs) could emit variable fluorescence in the NIR-II window due to their narrow band gap. Unfortunately, the fluorescence in the NIR-IIb region was not strong enough to image in vivo because the lattice defects on the surface of Ag2Te increased non-radiative transitions and decreased fluorescence performance. In this work, we coated a Ag2Te core with a Ag2Se shell to passivate the lattice defects and enhance its fluorescence efficiency. The fluorescence property of the as-prepared Ag2Te/Ag2Se core/shell QDs is more than 10 times stronger than that of Ag2Te. The brighter Ag2Te/Ag2Se QDs showed high-resolution in vivo imaging in the NIR-IIb region to distinguish thin blood vessels up to 66 μm. Overall, Ag2Te/Ag2Se QDs with excellent fluorescence in the NIR-IIb region were prepared and showed great potential for biomedical imaging.
中文翻译：
用于近红外 IIb 区域高分辨率体内荧光成像的核/壳结构 Ag2Te/Ag2Se 量子点
近红外 IIb 窗口（NIR-IIb，1500–1700 nm）中的荧光显示出更高的信噪比、更好的时空分辨率和更深的组织穿透力。然而，在NIR-IIb区域具有优异荧光性能的材料却鲜有报道。Ag 2 Te 量子点（QD）由于其窄带隙可以在 NIR-II 窗口中发射可变荧光。不幸的是，NIR-IIb 区域的荧光强度不足以进行体内成像，因为 Ag 2 Te表面的晶格缺陷增加了非辐射跃迁并降低了荧光性能。在这项工作中，我们在 Ag 2 Te 核上涂覆了 Ag 2Se壳钝化晶格缺陷并提高其荧光效率。所制备的Ag 2 Te/Ag 2 Se核/壳量子点的荧光性能比Ag 2 Te强10倍以上。更亮的 Ag 2 Te/Ag 2 Se QD 在 NIR-IIb 区域显示出高分辨率的体内成像，可区分直径达 66 μm 的细血管。总体而言，制备了在NIR-IIb区域具有优异荧光的Ag 2 Te/Ag 2 Se QD，并在生物医学成像方面显示出巨大的潜力。
更新日期：2023-08-02
中文翻译：
用于近红外 IIb 区域高分辨率体内荧光成像的核/壳结构 Ag2Te/Ag2Se 量子点
近红外 IIb 窗口（NIR-IIb，1500–1700 nm）中的荧光显示出更高的信噪比、更好的时空分辨率和更深的组织穿透力。然而，在NIR-IIb区域具有优异荧光性能的材料却鲜有报道。Ag 2 Te 量子点（QD）由于其窄带隙可以在 NIR-II 窗口中发射可变荧光。不幸的是，NIR-IIb 区域的荧光强度不足以进行体内成像，因为 Ag 2 Te表面的晶格缺陷增加了非辐射跃迁并降低了荧光性能。在这项工作中，我们在 Ag 2 Te 核上涂覆了 Ag 2Se壳钝化晶格缺陷并提高其荧光效率。所制备的Ag 2 Te/Ag 2 Se核/壳量子点的荧光性能比Ag 2 Te强10倍以上。更亮的 Ag 2 Te/Ag 2 Se QD 在 NIR-IIb 区域显示出高分辨率的体内成像，可区分直径达 66 μm 的细血管。总体而言，制备了在NIR-IIb区域具有优异荧光的Ag 2 Te/Ag 2 Se QD，并在生物医学成像方面显示出巨大的潜力。
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