CD8+ T cell killing of MHC class I–deficient tumors,Nature Cancer

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CD8+ T cell killing of MHC class I–deficient tumors
Nature Cancer ( IF 23.5 ) Pub Date : 2023-08-03 , DOI: 10.1038/s43018-023-00606-y
Christopher E Rudd _{1,

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Affiliation

CD8+ T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8+ T cells eliminate cancer cells deficient in MHC class I has been unclear. A study now shows that adaptive CD8+ T cell activation induces expression of the innate receptor NKG2D for the elimination of MHC class I–deficient tumors.

中文翻译：

CD8+ T 细胞杀伤 MHC I 类缺陷肿瘤

CD8+ T 细胞识别由主要组织相容性复合体 (MHC) I 类分子呈递的肿瘤相关抗原。CD8+ T 细胞如何消除 MHC I 类缺陷的癌细胞尚不清楚。现在的一项研究表明，适应性 CD8+ T 细胞激活可诱导先天受体 NKG2D 的表达，从而消除 MHC I 类缺陷的肿瘤。

更新日期：2023-08-03

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