REG1A 保护视网膜感光细胞免受蓝光损伤,Annals of the New York Academy of Sciences

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REG1A 保护视网膜感光细胞免受蓝光损伤
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2023-08-02 , DOI: 10.1111/nyas.15045
Ze-Hua Xu ₁ , Hang Zhang ₁ , Chang-Jun Zhang ₁ , Si-Jian Yu ₁ , Jing Yuan ₁ , Kangxin Jin ₁ , Zi-Bing Jin ₁

Affiliation

随着人造光的使用增加和光电产品的长期使用，人类视网膜的光损伤（LD）已被确定为威胁全球视力的问题。虽然有证据表明，光诱发的视网膜损伤与年龄相关性黄斑变性中的年龄相关性视力障碍之间存在显着相关性，但尚不清楚光诱发的视网膜变性如何表现，以及是否有药物能够预防 LD 的发展在视网膜中。这项研究调查了蓝光导致光感受器死亡的机制。通过观察视网膜类器官和感光细胞的蓝光暴露，我们得出结论，感光细胞可能存在显着的凋亡。我们证明，再生胰岛源性 1 α (REG1A) 通过增加抗凋亡基因Bcl2的表达并下调促凋亡基因Bax的表达来防止光感受器经历这种 LD 诱导的细胞凋亡，从而减少线粒体损伤并改善有氧运动感光细胞的能力。REG1A 首次被证明可以在 LD 引起的损伤后恢复线粒体功能和细胞凋亡，表明其在预防和治疗视网膜视力丧失方面的潜在应用。

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REG1A protects retinal photoreceptors from blue light damage

With the increased use of artificial light and the prolonged use of optoelectronic products, light damage (LD) to the human retina has been identified as a global vision-threatening problem. While there is evidence of a significant correlation between light-induced retinal damage and age-related vision impairment in age-related macular degeneration, it is unclear how light-induced retinal degeneration manifests itself and whether there are agents capable of preventing the development of LD in the retina. This study investigated a mechanism by which blue light leads to photoreceptor death. By observing blue light exposure in retinal organoids and photoreceptor cells, we concluded that there could be significant apoptosis of the photoreceptors. We demonstrate that regenerating islet-derived 1 alpha (REG1A) prevents photoreceptors from undergoing this LD-induced apoptosis by increasing expression of the anti-apoptotic gene Bcl2 and downregulating expression of the pro-apoptotic gene Bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. For the first time, REG1A has been shown to restore mitochondrial function and cell apoptosis after LD-induced damage, suggesting its potential application in the prevention and treatment of retinal vision loss.

更新日期：2023-08-02

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