<br>十溴二苯醚（BDE-209）诱导的男性生殖毒性的综合评价：来自啮齿动物研究的证据,Science of the Total Environment

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十溴二苯醚（BDE-209）诱导的男性生殖毒性的综合评价：来自啮齿动物研究的证据
Science of the Total Environment ( IF 8.2 ) Pub Date : 2023-08-02 , DOI: 10.1016/j.scitotenv.2023.165938
Debarshi Sarkar ₁ , Parul Midha ₁ , Shashanka Sekhar Shanti ₁ , Shio Kumar Singh ₂

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多溴联苯醚（PBDE）是一类溴化阻燃剂（BFR），用于各种制成品中，以防止火灾、减缓其蔓延并减少由此造成的损害。十溴二苯醚（BDE-209）是 PBDE 的一个例子，约占 PBDE 总产量的 82%。BDE-209 是一种甲状腺激素（TH）干扰化学物质，因为它的结构与 TH 相似。目前，由于 BDE-209 的广泛使用，生物样品中 BDE-209 水平的增加已成为一个主要问题。BDE-209 主要通过损害类固醇生成、产生氧化应激（OS）和干扰生殖细胞动力学引起男性生殖毒性。此外，接触这种化学物质会影响小鼠睾丸的代谢状态、精子浓度、各种发育基因的表观遗传调控和血液睾丸屏障的完整性。然而，BDE-209 及其作用机制对男性生殖健康的可能不利影响尚未得到严格评估。因此，本综述文章在现有文献的帮助下，旨在阐明 BDE-209 与啮齿动物甲状腺功能障碍相关的生殖毒性。此外，为了加强我们对 BDE-209 诱导的男性生殖毒性的了解，还强调了几个关键途径。数据是从 PubMed、Web of Science 和其他数据库中可用的科学文章中提取的。彻底了解 BDE-209 暴露的风险评估及其作用机制对于提高对这种 BFR 保持男性生育能力的潜在威胁至关重要。

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A comprehensive review on the decabromodiphenyl ether (BDE-209)-induced male reproductive toxicity: Evidences from rodent studies

Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants (BFRs), are employed in various manufactured products to prevent fires, slow down their spread and reduce the resulting damages. Decabromodiphenyl ether (BDE-209), an example of PBDEs, accounts for approximately 82 % of the total production of PBDEs. BDE-209 is a thyroid hormone (TH)-disrupting chemical owing to its structural similarity with TH. Currently, increase in the level of BDE-209 in biological samples has become a major issue because of its widespread use. BDE-209 causes male reproductive toxicity mainly via impairment of steroidogenesis, generation of oxidative stress (OS) and interference with germ cell dynamics. Further, exposure to this chemical can affect metabolic status, sperm concentration, epigenetic regulation of various developmental genes and integrity of blood-testis barrier in murine testis. However, the possible adverse effects of BDE-209 and its mechanism of action on the male reproductive health have not yet been critically evaluated. Hence, the present review article, with the help of available literature, aims to elucidate the reproductive toxicity of BDE-209 in relation to thyroid dysfunction in rodents. Further, several crucial pathways have been also highlighted in order to strengthen our knowledge on BDE-209-induced male reproductive toxicity. Data were extracted from scientific articles available in PubMed, Web of Science, and other databases. A thorough understanding of the risk assessment of BDE-209 exposure and mechanisms of its action is crucial for greater awareness of the potential threat of this BFR to preserve male fertility.

更新日期：2023-08-02

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