用于 3D 打印的水性磷酸钙水泥油墨,Advanced Engineering Materials

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用于 3D 打印的水性磷酸钙水泥油墨
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2023-08-01 , DOI: 10.1002/adem.202300789
Jan Weichhold ₁ , Maximilian Pfeiffle ₁ , Juliane C. Kade ₁ , Katrin Hurle ₂ , Uwe Gbureck ₁

Affiliation

模仿天然骨的天然特性和结构是再生医学领域仍然存在的挑战。由于磷酸钙骨水泥 (CPC) 与骨矿物质的化学相似性，这些骨水泥作为潜在的骨替代材料得到了深入研究。然而，由于反应时间慢、设计自由度有限以及通过细喷嘴喷射时的压滤等制造问题，将 CPC 加工和处理成具有足够 3D 打印性能的预制浆料存在缺陷。本文提出了一种含有α-磷酸三钙粉末的水性水泥浆，其通过焦磷酸钠(Na ₄ P ₂ O ₇ ·10H ₂ O)作为添加剂进行稳定。由于浆料中的高粉末负载量可能会导致挤出过程中的压滤，因此在水泥浆中添加不同浓度和分子量的透明质酸 (HyAc)，从而减少基于 3D 挤出的打印过程中的压滤。通过等温量热法和 X 射线衍射研究这些水泥浆在用正磷酸盐溶液活化后的凝固反应，以及使用 Imeter 测量的硬化性能，同时通过 1.2 和 0.8 mm 插管挤出来评估可加工性。具有适当 HyAc 分子量和浓度的 3D 打印结构表现出适合临床应用的机械性能和分辨率。

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Aqueous Calcium Phosphate Cement Inks for 3D Printing

Mimicking the native properties and architecture of natural bone is a remaining challenge within the field of regenerative medicine. Due to the chemical similarity of calcium phosphate cements (CPCs) to bone mineral, these cements are well studied as potential bone replacement material. Nevertheless, the processing and handling of CPCs into prefabricated pastes with adequate properties for 3D printing has drawbacks due to slow reaction times, limited design freedom, as well as fabrication issues such as filter pressing during ejection through thin nozzles. Herein, an aqueous cement paste containing α-tricalcium phosphate powder is proposed, which is stabilized by sodium pyrophosphate (Na₄P₂O₇·10H₂O) as additive. Since high powder loadings within pastes can result in filter pressing during extrusion, various concentrations and molecular weights of hyaluronic acid (HyAc) are added to the cement paste, resulting in reduced filter pressing during 3D extrusion-based printing. These cement pastes are investigated regarding their setting reaction after activation with orthophosphate solution by isothermal calorimetry and X-ray diffraction, as well as their hardening performance using Imeter measurements, while the processability is assessed by extrusion through 1.2 and 0.8 mm cannulas. The 3D-printed structures with appropriate HyAc molecular weight and concentration demonstrate suitable mechanical properties and resolution for clinical application.

更新日期：2023-08-01

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