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Effect of Diabetic Neuropathy on Reparative Ability and Immune Response System
Molecular Biotechnology ( IF 2.4 ) Pub Date : 2023-07-31 , DOI: 10.1007/s12033-023-00813-z
Emina Karahmet Sher 1 , Besim Prnjavorac 2 , Esma Karahmet Farhat 3, 4 , Benjamin Palić 5 , Sabah Ansar 6 , Farooq Sher 7
Affiliation  

The effects of diabetes can be divided into short, medium and long term and various human organ systems can be effected. The present study aimed to determine how much the duration of diabetes mellitus (DM) affect the reparative ability of the body, immune response and the development of DM complications. Interleukin 1-β (IL-1β) and Interleukin 6 (IL-6) were monitored as specific indicators of inflammatory reaction and C-reactive protein (CRP), leukocyte count (WBC) and sedimentation rate (ESR) as general markers of inflammatory reaction. Tumour necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1) were observed as indicators of reparative ability and polyneuropathy. All interleukins were determined by ELISA and evaluated spectrophotometrically. Michigan Neuropathy Screening Instrument (MNSI) is performed for neuropathy examination. Patients with diabetes mellitus were divided into 3 groups, according to duration of diabetes mellitus. IL-6 levels correlated with clinical stage of diabetic polyneuropathy at p = 0.025 R = 0.402; with CRP at p = 0.0001, R = 0.784 as well as correlation of CRP and MNSI score (R = 0.500, p = 0.034) in a group of patients with DM lasting up to 10 years. The reparative ability of the body is reduced by physiological age and ages of DM duration. The immune response is weakened in DM additionally. The dual activity of cytokines IL-6 and TGF-β1 is present in long-duration Diabetes Mellitus.



中文翻译:

糖尿病神经病变对修复能力和免疫反应系统的影响

糖尿病的影响可分为短期、中期和长期,可影响人体各器官系统。本研究旨在确定糖尿病 (DM) 病程对身体修复能力、免疫反应和 DM 并发症发生的影响程度。监测白细胞介素1-β(IL-1β)和白细胞介素6(IL-6)作为炎症反应的具体指标,监测C反应蛋白(CRP)、白细胞计数(WBC)和沉降率(ESR)作为炎症反应的一般标志物。反应。观察肿瘤坏死因子α(TNF-α)和转化生长因子β1(TGF-β1)作为修复能力和多发性神经病的指标。所有白细胞介素均通过 ELISA 测定并通过分光光度法评估。密歇根神经病变筛查仪(MNSI)用于神经病变检查。根据糖尿病病程的不同,糖尿病患者被分为 3 组。IL-6 水平与糖尿病性多发性神经病的临床分期相关,p  = 0.025 R  = 0.402; 在一组持续长达 10 年的 DM 患者中,CRP 为p  = 0.0001,R  = 0.784,以及 CRP 与 MNSI 评分的相关性(R  = 0.500,p = 0.034)。身体的修复能力随着生理年龄和DM持续时间的年龄而降低。DM 中的免疫反应也被削弱。长期糖尿病中存在细胞因子 IL-6 和 TGF-β1 的双重活性。

更新日期:2023-07-31
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