In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing conductive antibacterial hydrogel dressings based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe³⁺ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair of infected wound. The Schiff base and Fe³⁺ coordination bonds of the hydrogel structure are dynamic bonds that can be repaired automatically after the hydrogel network is disrupted. Macroscopically, the hydrogel exhibits self-healing properties, allowing the hydrogel dressing to adapt to complex wound surfaces. The OSD/CMC/Fe/PA hydrogel showed good conductivity and photothermal antibacterial properties under near-infrared (NIR) light irradiation. In addition, the hydrogels exhibit tunable rheological properties, suitable mechanical properties, antioxidant properties, tissue adhesion properties and hemostatic properties. Furthermore, all hydrogel dressings improved wound healing in the infected full-thickness defect skin wound repair test in mice. The wound size repaired by OSD/CMC/Fe/PA3 hydrogel + NIR was much smaller (12%) than the control group treated with Tegaderm™ film after 14 days. In conclusion, the hydrogels have high antibacterial efficiency, suitable conductivity, great self-healing properties, good biocompatibility, hemostasis and antioxidant properties, making them promising candidates for wound healing dressings for the treatment of infected skin wounds.

在临床应用中，缺乏兼具高效抵抗耐药菌和良好自愈性能的伤口敷料。本研究开发了一系列基于氧化海藻酸钠接枝多巴胺/羧甲基壳聚糖/Fe ³⁺ (OSD/CMC/Fe水凝胶)/聚多巴胺封装聚(噻吩-3-乙酸)的粘性自愈导电抗菌水凝胶敷料。 ）（OSD/CMC/Fe/PA水凝胶）用于修复感染伤口。水凝胶结构的希夫碱和Fe ³⁺配位键是动态键，水凝胶网络被破坏后可以自动修复。宏观上，水凝胶表现出自愈特性，使水凝胶敷料能够适应复杂的伤口表面。OSD/CMC/Fe/PA水凝胶在近红外（NIR）光照射下表现出良好的导电性和光热抗菌性能。此外，水凝胶还表现出可调节的流变特性、合适的机械特性、抗氧化特性、组织粘附特性和止血特性。此外，在小鼠感染的全层缺损皮肤伤口修复试验中，所有水凝胶敷料均改善了伤口愈合。14 天后，OSD/CMC/Fe/PA3 水凝胶 + NIR 修复的伤口尺寸比使用 Tegaderm™ 薄膜治疗的对照组小得多 (12%)。总之，水凝胶具有高抗菌效率、合适的导电性、良好的自愈特性、良好的生物相容性、止血和抗氧化特性，使其成为治疗感染皮肤伤口的伤口愈合敷料的有希望的候选者。