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Sequence Specific DNA Cross-Linking Triggered by Visible Light
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2012-06-25 , DOI: 10.1021/ja301901p Marieke Op de Beeck 1 , Annemieke Madder 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2012-06-25 , DOI: 10.1021/ja301901p Marieke Op de Beeck 1 , Annemieke Madder 1
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A new biocompatible strategy for photoinduced DNA interstrand cross-linking is presented. Methylene blue induced (1)O(2) formation triggers furan oxidation; the resulting aldehyde then rapidly reacts with complementary A or C with formation of stable adducts. Easily accessible furan modified nucleosides, a commercially available photosensitizer, and visible light irradiation constitute the necessary tools to achieve selective duplex interstrand cross-linking.
中文翻译：
可见光触发的序列特异性 DNA 交联
提出了一种用于光诱导 DNA 链间交联的新生物相容性策略。亚甲蓝诱导 (1)O(2) 形成触发呋喃氧化；生成的醛然后与互补的 A 或 C 快速反应，形成稳定的加合物。易于获得的呋喃修饰核苷、市售光敏剂和可见光照射构成了实现选择性双链间交联的必要工具。
更新日期：2012-06-25
中文翻译：
可见光触发的序列特异性 DNA 交联
提出了一种用于光诱导 DNA 链间交联的新生物相容性策略。亚甲蓝诱导 (1)O(2) 形成触发呋喃氧化；生成的醛然后与互补的 A 或 C 快速反应，形成稳定的加合物。易于获得的呋喃修饰核苷、市售光敏剂和可见光照射构成了实现选择性双链间交联的必要工具。
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