<br>揭示细胞骨架蛋白在中性粒细胞胞外陷阱形成中的作用,International Immunopharmacology

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揭示细胞骨架蛋白在中性粒细胞胞外陷阱形成中的作用
International Immunopharmacology ( IF 4.8 ) Pub Date : 2023-07-27 , DOI: 10.1016/j.intimp.2023.110607
Changlin Du ₁ , Na Cai ₁ , Jiahui Dong ₁ , Chuanting Xu ₁ , Qi Wang ₁ , Zhenming Zhang ₁ , Jun Li ₁ , Cheng Huang ₁ , Taotao Ma ₁

Affiliation

中性粒细胞是一种参与先天免疫防御的淋巴细胞。为了响应特定刺激，这些吞噬细胞会经历一种独特的细胞死亡形式，即 NETosis，在此期间，它们会释放由修饰的染色质结构修饰的染色质结构组成的中性粒细胞胞外陷阱（NETs），这些细胞胞浆和颗粒蛋白装饰。多种蛋白质和途径与 NET 的形成有关。细胞骨架是丝状聚合物和调节蛋白的互连网络，在真核细胞运动过程中抵抗变形、运输细胞内货物和改变形状方面起着至关重要的作用。它也可能已经进化为保护真核生物免受感染。最近的研究重点是通过识别触发 NETosis 或与 NETs 相互作用并通过细胞骨架动力学影响细胞行为的酶，了解 NETs 形成的潜在机制以及细胞骨架网络如何促进这一过程。对细胞骨架和 NET 形成之间复杂关系的加深理解将为未来的研究和靶向治疗策略的开发提供一个框架，并支持长寿命细胞骨架结构可能对该研究领域产生持久影响的观点。

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Uncovering the role of cytoskeleton proteins in the formation of neutrophil extracellular traps

Neutrophils are a type of lymphocyte involved in innate immune defense. In response to specific stimuli, these phagocytic cells undergo a unique form of cell death, NETosis, during which they release neutrophil extracellular traps (NETs) composed of modified chromatin structures decorated with cytoplasmic and granular proteins. Multiple proteins and pathways have been implicated in the formation of NETs. The cytoskeleton, an interconnected network of filamentous polymers and regulatory proteins, plays a crucial role in resisting deformation, transporting intracellular cargo, and changing shape during movement of eukaryotic cells. It may also have evolved to defend eukaryotic organisms against infection. Recent research focuses on understanding the mechanisms underlying NETs formation and how cytoskeletal networks contribute to this process, by identifying enzymes that trigger NETosis or interact with NETs and influence cellular behavior through cytoskeletal dynamics. An enhanced understanding of the complex relationship between the cytoskeleton and NET formation will provide a framework for future research and the development of targeted therapeutic strategies, and supports the notion that the long-lived cytoskeleton structures may have a lasting impact on this area of research.

更新日期：2023-07-27

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