Not just Glia—Dissecting brain macrophages in the mouse,Glia

当前位置： X-MOL 学术 › Glia › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Not just Glia—Dissecting brain macrophages in the mouse
Glia ( IF 5.4 ) Pub Date : 2023-07-28 , DOI: 10.1002/glia.24445
Gal Ronit Frumer ₁ , Sun-Hye Shin ₁ , Steffen Jung ₁ , Jung-Seok Kim ₁

Affiliation

Macrophages have emerged as critical cellular components of the central nervous system (CNS), promoting development, maintenance, and immune defense of the CNS. Here we will review recent advances in our understanding of brain macrophage heterogeneity, including microglia and border-associated macrophages, focusing on the mouse. Emphasis will be given to the discussion of strengths and limitations of the experimental approaches that have led to the recent insights and hold promise to further deepen our mechanistic understanding of brain macrophages that might eventually allow to harness their activities for the management of CNS pathologies.

中文翻译：

不仅仅是神经胶质细胞——解剖小鼠大脑巨噬细胞

巨噬细胞已成为中枢神经系统 (CNS) 的关键细胞成分，促进中枢神经系统的发育、维持和免疫防御。在这里，我们将回顾我们对大脑巨噬细胞异质性（包括小胶质细胞和边界相关巨噬细胞）理解的最新进展，重点关注小鼠。重点将讨论实验方法的优点和局限性，这些实验方法产生了最近的见解，并有望进一步加深我们对脑巨噬细胞的机制理解，最终可能利用它们的活动来管理中枢神经系统病理。

更新日期：2023-07-28

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南