Photothermal theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient antibacterial treatment,RSC Advances

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Photothermal theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient antibacterial treatment
RSC Advances ( IF 3.9 ) Pub Date : 2023-07-28 , DOI: 10.1039/d3ra03246a
Yuelan Wu _{1,

2} , Xiaoxue Liu _{2,

3} , Xiaoyu Zhang _{2,

3} , Shuping Zhang _{3,

4} , Panhong Niu ₄ , Hua Gao _{1,

2,

3}

Affiliation

Drug-resistant bacteria caused by the abuse of antibiotics have brought great challenges to antimicrobial therapy. Herein an antibiotic-free polydopamine (PDA) modified metal–organic framework (PDA-FDM-23) with photothermal-enhanced chemodynamic effect was developed for synergistic antibacterial treatment. The PDA-FDM-23 antibacterial agent exhibited high peroxidase-like activity. Moreover, the process was significantly accelerated by consuming glutathione (GSH) to generate more efficient oxidizing Cu⁺. In addition, the photothermal therapy (PTT) derived from PDA improved the chemodynamic therapy (CDT) activity triggering a reactive oxygen species explosion. This PTT-enhanced CDT strategy illustrated 100% antibacterial efficiency against both Staphylococcus aureus and Escherichia coli. Cytotoxicity and hemolysis analyses fully demonstrated the excellent biocompatibility of PDA-FDM-23. Overall, our work highlighted the strong peroxidase catalytic activity, excellent GSH consumption and photothermal performance of PDA-FDM-23, providing a new strategy for antibiotic-free reactive oxygen species (ROS) synergistic sterilization.

中文翻译：

具有谷胱甘肽消耗和增强活性氧生成的光热治疗诊断法，可实现有效的抗菌治疗

滥用抗生素引起的耐药菌给抗菌治疗带来了巨大挑战。本文开发了一种具有光热增强化学动力学效应的无抗生素聚多巴胺（PDA）修饰的金属有机框架（PDA-FDM-23），用于协同抗菌治疗。PDA-FDM-23抗菌剂表现出高过氧化物酶样活性。^{此外，通过消耗谷胱甘肽（GSH）以产生更有效的氧化性 Cu +}，该过程显着加速。此外，PDA 衍生的光热疗法 (PTT) 改善了化学动力学疗法 (CDT) 活性，引发活性氧爆炸。这种 PTT 增强的 CDT 策略对金黄色葡萄球菌和大肠杆菌均具有 100% 的抗菌效率。细胞毒性和溶血分析充分证明了PDA-FDM-23优异的生物相容性。总体而言，我们的工作突出了PDA-FDM-23强大的过氧化物酶催化活性、优异的GSH消耗和光热性能，为无抗生素活性氧（ROS）协同灭菌提供了新策略。

更新日期：2023-07-28

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