Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-07-27 , DOI: 10.1021/jacs.3c03418
Weiyang Guan ₁ , Yejin Chang ₁ , Song Lin ₁

Affiliation

We present a new, unified approach for the transformation of benzylic and allylic alcohols, aldehydes, and ketones into boronic esters under electroreductive conditions. Key to our strategy is the use of readily available pinacolborane, which serves both as an activator and an electrophile by first generating a redox-active trialkylborate species and then delivering the desired deoxygenatively borylated product. This strategy is applicable to a variety of substrates and can be employed for the late-stage functionalization of complex molecules.

中文翻译：

电化学驱动的醇和羰基化合物的脱氧硼化反应

我们提出了一种新的、统一的方法，用于在电还原条件下将苄醇和烯丙醇、醛和酮转化为硼酸酯。我们策略的关键是使用容易获得的频那醇硼烷，它首先生成氧化还原活性三烷基硼酸盐物质，然后提供所需的脱氧硼酸化产物，从而既充当活化剂又充当亲电子试剂。该策略适用于各种底物，并且可用于复杂分子的后期功能化。

更新日期：2023-07-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南