Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism,Journal of Natural Products

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Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism
Journal of Natural Products ( IF 3.3 ) Pub Date : 2023-07-27 , DOI: 10.1021/acs.jnatprod.3c00466
Hongbo Dong _{1,

2} , Pei Yu ₁ , Bin Long ₁ , Ting Peng ₂ , Yujiao He ₂ , Bing Xu ₃ , Li Liao ₂ , Lan Lu ₂

Affiliation

Kuwanons A (1) and B (2) are two natural prenylated flavones isolated from the root bark of Morus alba L. In this study, the first total syntheses of kuwanons A (1) and B (2) were achieved from a common intermediate with overall yields of 6.6% and 11.6%, respectively. Kuwanon B (2) exhibited antibacterial activity against Gram-positive bacteria and concentration-dependent bactericidal activity against Staphylococcus aureus bacteria. Preliminary mechanism of action studies suggested that this compound killed bacteria rapidly by disrupting bacterial membrane integrity

中文翻译：

桑酮A和B的全合成及其抗菌机制的发现

桑酮 A ( 1 ) 和 B ( 2 ) 是从桑树根皮中分离出来的两种天然异戊二烯化黄酮。在本研究中，桑酮 A ( 1 ) 和 B ( 2 ) 的首次全合成是从共同的中间体中实现的。总收益率分别为6.6%和11.6%。 Kuwanon B ( 2 ) 对革兰氏阳性菌具有抗菌活性，对金黄色葡萄球菌具有浓度依赖性杀菌活性。初步作用机制研究表明，该化合物通过破坏细菌膜完整性来快速杀死细菌

更新日期：2023-07-27

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