Massage protects skeletal muscle from injury during long-term heavy-duty exercise via integrin β1 and laminin 2 channels of basement membrane,BMC Complementary and Alternative Medicine

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Massage protects skeletal muscle from injury during long-term heavy-duty exercise via integrin β1 and laminin 2 channels of basement membrane
BMC Complementary and Alternative Medicine Pub Date : 2023-07-26 , DOI: 10.1186/s12906-023-04094-6
Qingsong Liu _{1,

2} , Songlin Jin ₂ , Lunyu Li ₂ , Liubu Ayi ₂ , Haili Ding ₃

Affiliation

Massage is widely used in exercise-induced skeletal muscle damage (EIMD). It has been proven that massage can improve the morphology and function of damaged skeletal muscle in multiple ways. However, whether massage can protect skeletal muscles from injury during long-term heavy-duty exercise has not yet been determined. In this study, a rat model of overuse injury was established by eccentric running for 4 weeks, and pressing at constant pressure and frequency and massage were used as intervention methods to explore whether massage could protect skeletal muscle from injury through upregulating integrin and the basement membrane laminin. The results showed that compared with the model group, the ultrastructure of skeletal muscle in the massage group was relatively complete and clear, and the maximum isotonic and tetanic contraction forces were significantly increased (P < 0.01). In addition, in the massage group, β1 integrin expression was significantly increased, p-FAK protein expression was decreased, and the co-localization of β1 integrin and the basement membrane laminin 2 was significantly increased (P < 0.01). Our study shows that during long-term heavy-duty exercise, massage can enhance the cell adhesion function mediated by integrin β1 and laminin 2 to protect skeletal muscle from injury and prevent the occurrence of overuse injury.

中文翻译：

按摩通过基底膜整合素β1和层粘连蛋白2通道保护骨骼肌在长期大负荷运动中免受损伤

按摩广泛用于治疗运动引起的骨骼肌损伤（EIMD）。事实证明，按摩可以通过多种方式改善受损骨骼肌的形态和功能。然而，按摩是否可以保护骨骼肌在长期大负荷运动中免受损伤尚未确定。本研究通过4周的离心跑建立大鼠过度使用损伤模型，并采用恒压恒频按压和按摩作为干预方法，探讨按摩是否可以通过上调整合素和基底膜来保护骨骼肌免受损伤。层粘连蛋白。结果显示，与模型组相比，按摩组骨骼肌超微结构相对完整、清晰，最大等张力和强直收缩力显着增加（P < 0.01）。此外，按摩组β1整合素表达量显着升高，p-FAK蛋白表达量降低，β1整合素与基底膜层粘连蛋白2的共定位显着增加（P < 0.01）。我们的研究表明，在长期大强度运动过程中，按摩可以增强整合素β1和层粘连蛋白2介导的细胞粘附功能，从而保护骨骼肌免受损伤，防止过度使用损伤的发生。

更新日期：2023-07-26

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