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Ent-eudesmane sesquiterpenoids from the Chinese liverwort Chiloscyphus polyanthus
Phytochemistry ( IF 3.2 ) Pub Date : 2023-07-25 , DOI: 10.1016/j.phytochem.2023.113796 Ming-Zhu Zhu 1 , Yi Li 1 , Jin-Chuan Zhou 2 , Dong-Xue Lv 1 , Xiao-Jie Fu 1 , Zhen Liang 1 , Shuang-Zhi Yuan 1 , Jing-Jing Han 1 , Jiao-Zhen Zhang 1 , Ze-Jun Xu 1 , Wen-Qiang Chang 1 , Hong-Xiang Lou 1
更新日期：2023-07-27
Phytochemistry ( IF 3.2 ) Pub Date : 2023-07-25 , DOI: 10.1016/j.phytochem.2023.113796 Ming-Zhu Zhu 1 , Yi Li 1 , Jin-Chuan Zhou 2 , Dong-Xue Lv 1 , Xiao-Jie Fu 1 , Zhen Liang 1 , Shuang-Zhi Yuan 1 , Jing-Jing Han 1 , Jiao-Zhen Zhang 1 , Ze-Jun Xu 1 , Wen-Qiang Chang 1 , Hong-Xiang Lou 1
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− Seven previously undescribed ent-eudesmane sesquiterpenoids (1–7), as well as seven known analogs (8–14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive spectroscopy analysis, electronic circular dichroism calculations, as well as biosynthetic considerations. The cytotoxicity against HepG2 (Human hepatocellular carcinomas) cancer cell line, and antifungal activity against Candida albicans SC5314 of all isolated ent-eudesmane sesquiterpenoids were preliminarily tested, results showed that the tested compounds did not display obvious cytotoxicity and antifungal activities under the tested concentration.
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