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In situ Injectable Tetra-PEG Hydrogel Bioadhesive for Sutureless Repair of Gastrointestinal Perforation†
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2023-07-25 , DOI: 10.1002/cjoc.202300312 Shurong Li 1 , Yiwen Xian 1 , Gang He 1, 2 , Luyuan Chen 2 , Zhihui Chen 2 , Yonglong Hong 2 , Chong Zhang 1 , Decheng Wu 1
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2023-07-25 , DOI: 10.1002/cjoc.202300312 Shurong Li 1 , Yiwen Xian 1 , Gang He 1, 2 , Luyuan Chen 2 , Zhihui Chen 2 , Yonglong Hong 2 , Chong Zhang 1 , Decheng Wu 1
Affiliation
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Hydrogel bioadhesives represent promising and efficient alternatives to sutures or staples for gastrointestinal (GI) perforation management. However, several concerns remain for the existing bioadhesives including slow and/or weak adhesive, poor mechanical strength, low biocompatibility, and poor biodegradability, which largely limit their clinical application in GI perforation repair. In this work, we introduce an in situ injectable Tetra-PEG hydrogel bioadhesive (SS) composed of tetra-armed poly(ethylene glycol) amine (Tetra-PEG-NH2) and tetra-armed poly(ethylene glycol) succinimidyl succinate (Tetra-PEG-SS) for the sutureless repair of GI defects. The SS hydrogel exhibits rapid gelation behavior and high burst pressure and is capable of providing instant robust adhesion and fluid-tight sealing in the ex vivo porcine intestinal and gastric models. Importantly, the succinyl ester linkers in the SS hydrogel endow the bioadhesive with suitable in vivo degradability to match the new GI tissue formation. The in vivo evaluation in the rat GI injured model further demonstrates the successful sutureless sealing and repair of the intestine and stomach by the SS hydrogel with the advantages of neglectable postsurgical adhesion, suppressed inflammation, and enhanced angiogenesis. Together, our results support potential clinical applications of the SS bioadhesive for the high-efficient repair of GI perforation.
中文翻译：
原位注射 Tetra-PEG 水凝胶生物粘合剂用于无缝修复胃肠穿孔†
水凝胶生物粘合剂代表了用于胃肠道（GI）穿孔管理的缝线或钉书钉的有前途且有效的替代品。然而，现有的生物粘合剂仍然存在一些问题，包括粘合速度慢和/或弱、机械强度差、生物相容性低和生物降解性差，这在很大程度上限制了其在胃肠道穿孔修复中的临床应用。在这项工作中，我们介绍了一种原位注射的Tetra-PEG水凝胶生物粘合剂（SS），由四臂聚乙二醇胺（Tetra-PEG-NH 2）和四臂聚乙二醇琥珀酰亚胺基琥珀酸酯（Tetra -PEG-SS）用于无缝修复胃肠道缺陷。SS 水凝胶表现出快速凝胶行为和高爆破压力，并且能够在离体猪肠和胃模型中提供即时牢固的粘附和液密密封。重要的是，SS水凝胶中的琥珀酯连接基赋予生物粘合剂适当的体内降解性，以匹配新的胃肠道组织的形成。大鼠胃肠道损伤模型的体内评估进一步证明了SS水凝胶成功地无缝密封和修复了肠胃，具有可忽略的术后粘连、抑制炎症和增强血管生成的优点。总之，我们的结果支持 SS 生物粘合剂在胃肠道穿孔高效修复方面的潜在临床应用。
更新日期：2023-07-25
中文翻译：
原位注射 Tetra-PEG 水凝胶生物粘合剂用于无缝修复胃肠穿孔†
水凝胶生物粘合剂代表了用于胃肠道（GI）穿孔管理的缝线或钉书钉的有前途且有效的替代品。然而，现有的生物粘合剂仍然存在一些问题，包括粘合速度慢和/或弱、机械强度差、生物相容性低和生物降解性差，这在很大程度上限制了其在胃肠道穿孔修复中的临床应用。在这项工作中，我们介绍了一种原位注射的Tetra-PEG水凝胶生物粘合剂（SS），由四臂聚乙二醇胺（Tetra-PEG-NH 2）和四臂聚乙二醇琥珀酰亚胺基琥珀酸酯（Tetra -PEG-SS）用于无缝修复胃肠道缺陷。SS 水凝胶表现出快速凝胶行为和高爆破压力，并且能够在离体猪肠和胃模型中提供即时牢固的粘附和液密密封。重要的是，SS水凝胶中的琥珀酯连接基赋予生物粘合剂适当的体内降解性，以匹配新的胃肠道组织的形成。大鼠胃肠道损伤模型的体内评估进一步证明了SS水凝胶成功地无缝密封和修复了肠胃，具有可忽略的术后粘连、抑制炎症和增强血管生成的优点。总之，我们的结果支持 SS 生物粘合剂在胃肠道穿孔高效修复方面的潜在临床应用。
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