3D 打印与共静电纺丝的集成：生物医学应用中的概念转变,ACS Omega

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3D 打印与共静电纺丝的集成：生物医学应用中的概念转变
ACS Omega ( IF 3.7 ) Pub Date : 2023-07-25 , DOI: 10.1021/acsomega.3c03920
Adrija Ghosh ₁ , Jonathan Tersur Orasugh _{2,

3} , Suprakas Sinha Ray _{2,

3} , Dipankar Chattopadhyay _{1,

4}

Affiliation

使用高效且适应性强的静电纺丝技术可以生产尺寸在亚微米和纳米尺度之间的多孔结构。然而，为了接近理想的结构，该结构缺乏机械复杂性和一致性，并且需要三维的单独或多功能结构。高性能聚合物和共混物的多样性使得能够创建多种多孔结构构象，用于先进材料科学，特别是生物医学中的应用。两种有前途的技术可以结合起来，例如静电纺丝与 3D 打印或增材制造，从而为数字控制形状变形制造提供一种简单而灵活的技术。配置的分层集成用于将复杂的形状和图案压印到介观结构、刺激响应的电纺织物上。该技术控制了面内和层间区域的膨胀/收缩失配引起的内应力，进而控制了电纺膜的形态特征。3D 打印和增材制造领域的重大创新催生了用于触觉和可穿戴传感器、过滤结构、结构健康监测传感器、组织工程、生物医学支架和光学图案的材料和支架系统的生产。这篇综述讨论了 3D 打印和静电纺丝之间的协同作用，作为快速结构原型的特定微加工方法的组成部分，这些原型有望进入下一代结构。此外，文献中从未讨论过单独的技术、其工艺参数以及所制造的新颖结构如何在生物医学领域整体应用。总之，这篇综述为静电纺丝和 3D 打印的使用及其在生物医学领域前沿应用的集成提供了新颖的见解。

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Integration of 3D Printing–Coelectrospinning: Concept Shifting in Biomedical Applications

Porous structures with sizes between the submicrometer and nanometer scales can be produced using efficient and adaptable electrospinning technology. However, to approximate desirable structures, the construction lacks mechanical sophistication and conformance and requires three-dimensional solitary or multifunctional structures. The diversity of high-performance polymers and blends has enabled the creation of several porous structural conformations for applications in advanced materials science, particularly in biomedicine. Two promising technologies can be combined, such as electrospinning with 3D printing or additive manufacturing, thereby providing a straightforward yet flexible technique for digitally controlled shape-morphing fabrication. The hierarchical integration of configurations is used to imprint complex shapes and patterns onto mesostructured, stimulus-responsive electrospun fabrics. This technique controls the internal stresses caused by the swelling/contraction mismatch in the in-plane and interlayer regions, which, in turn, controls the morphological characteristics of the electrospun membranes. Major innovations in 3D printing, along with additive manufacturing, have led to the production of materials and scaffold systems for tactile and wearable sensors, filtration structures, sensors for structural health monitoring, tissue engineering, biomedical scaffolds, and optical patterning. This review discusses the synergy between 3D printing and electrospinning as a constituent of specific microfabrication methods for quick structural prototypes that are expected to advance into next-generation constructs. Furthermore, individual techniques, their process parameters, and how the fabricated novel structures are applied holistically in the biomedical field have never been discussed in the literature. In summary, this review offers novel insights into the use of electrospinning and 3D printing as well as their integration for cutting-edge applications in the biomedical field.

更新日期：2023-07-25

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