An Integrated Therapeutic and Preventive Nanozyme-Based Microneedle for Biofilm-Infected Diabetic Wound Healing,Advanced Healthcare Materials

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An Integrated Therapeutic and Preventive Nanozyme-Based Microneedle for Biofilm-Infected Diabetic Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-07-21 , DOI: 10.1002/adhm.202301474
Caixia Sun ₁ , Xinyu Zhou ₁ , Cong Liu ₁ , Shuyue Deng ₁ , Yuhan Song ₂ , Jun Yang ₂ , Jianjun Dai _{1,

3} , Yanmin Ju ₁

Affiliation

The healing of biofilm-infected diabetic wounds characterized by a deteriorative tissue microenvironment represents a substantial clinical challenge. Current treatments remain unsatisfactory due to the limited antibiofilm efficacy caused by weak tissue and biofilm permeability of drugs and the risk of reinfection during the healing process. To address these issues, an integrated therapeutic and preventive nanozyme-based microneedle (denoted as Fe₂C/GOx@MNs) is engineered. The dissolvable tips with enough mechanical strength can deliver and rapidly release Fe₂C nanoparticles (NPs)/glucose oxidase (GOx) in the biofilm active regions, enhancing tissue and biofilm permeability of Fe₂C NPs/GOx, ultimately achieving highly efficient biofilm elimination. Meanwhile, the chitosan backing layer can not only act as an excellent physical barrier between the wound bed and the external environment, but also prevent the bacterial reinvasion during wound healing with its superior antibacterial property. Significantly, the biofilm elimination and reinfection prevention abilities of Fe₂C/GOx@MNs on wound healing are proved on methicillin-resistant Staphylococcus aureus-biofilm-infected diabetic mouse model with full-thickness wound. Together, these results demonstrate the promising clinical application of Fe₂C/GOx@MNs in biofilm-infected wound healing.

中文翻译：

一种基于纳米酶的综合治疗和预防微针，用于生物膜感染的糖尿病伤口愈合

以组织微环境恶化为特征的生物膜感染的糖尿病伤口的愈合是一个巨大的临床挑战。由于药物的组织和生物膜渗透性较弱以及愈合过程中存在再感染的风险，导致抗生物膜功效有限，目前的治疗方法仍然不能令人满意。为了解决这些问题，设计了一种基于纳米酶的综合治疗和预防微针（表示为 Fe ₂ C/GOx@MNs）。具有足够机械强度的可溶性吸头可以在生物膜活性区域递送并快速释放Fe ₂ C纳米颗粒（NPs）/葡萄糖氧化酶（GOx），增强组织和生物膜对Fe ₂ C NPs/GOx的通透性，最终实现高效生物膜消除。同时，壳聚糖背衬层不仅可以作为创面床与外部环境之间良好的物理屏障，而且以其优越的抗菌性能防止伤口愈合过程中细菌的再次侵入。值得注意的是，Fe ₂ C/GOx@MNs 对伤口愈合的生物膜消除和预防再感染的能力在耐甲氧西林金黄色葡萄球菌生物膜感染的全层伤口糖尿病小鼠模型上得到了证明。总之，这些结果证明了 Fe ₂ C/GOx@MNs 在生物膜感染伤口愈合中的有前景的临床应用。

更新日期：2023-07-21

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