Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics,Small Science

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Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics
Small Science ( IF 11.1 ) Pub Date : 2023-07-21 , DOI: 10.1002/smsc.202300052
Hanchen Shen ₁ , Changhuo Xu ₂ , Ruquan Ye ₃ , Tzu-Ming Liu ₂ , Jianyu Zhang ₁ , Ryan T. K. Kwok ₁ , Jacky W. Y. Lam ₁ , Zhihong Guo ₁ , Jianwei Sun ₁ , Ben Zhong Tang _{1,

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Affiliation

The development of water-soluble aggregation-induced emission luminogens (AIEgens) emitting in the near-infrared (NIR) window holds promise for efficient biomedical applications. Nevertheless, synthesizing water-soluble counterparts of NIR AIEgens presents difficulties due to their intrinsic hydrophobic properties. To address this issue, researchers have developed various molecular design strategies to improve the water solubility of NIR AIEgens. The integration of hydrophilic groups and targeting moieties is a crucial aspect of achieving precise phototheranostics. Here, diverse approaches to attain water-soluble NIR AIEgens for biomedical applications are presented, and three commonly used strategies that involve decorating NIR AIEgens with positively or negatively charged groups, hydrophilic chains, and bioactive moieties are elaborated. These rational design strategies are believed to provide solutions for enhancing the water solubility and biological performance of NIR AIEgens in a single action. The remaining challenges and opportunities in this field are also discussed. The aim is to provide new insights into the design of water-soluble NIR AIEgens and inspire more researchers to make significant contributions to this promising research area.

中文翻译：

用于先进光治疗学的具有近红外发射的水溶性聚集诱导发射发光剂

在近红外 (NIR) 窗口中发射的水溶性聚集诱导发射发光体 (AIEgens) 的开发为高效的生物医学应用带来了希望。然而，由于其固有的疏水性，合成近红外 AIEgens 的水溶性对应物存在困难。为了解决这个问题，研究人员开发了各种分子设计策略来提高 NIR AIEgens 的水溶性。亲水基团和靶向部分的整合是实现精确光治疗的关键方面。在这里，介绍了获得用于生物医学应用的水溶性近红外 AIEgen 的多种方法，并详细阐述了三种常用策略，包括用带正电或负电的基团、亲水链和生物活性部分修饰近红外 AIEgen。这些合理的设计策略被认为可以提供通过单次操作提高 NIR AIEgens 的水溶性和生物性能的解决方案。还讨论了该领域剩余的挑战和机遇。其目的是为水溶性近红外 AIEgens 的设计提供新的见解，并激励更多的研究人员为这一前景广阔的研究领域做出重大贡献。

更新日期：2023-07-21

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