Background

Famous synthetic pharmacophores like Filgotinib, Dapiprazole, and Trazodone have Triazolopyridine as their primary building element. It has become more well-known in medicinal chemistry, to which its broad-spectrum impact may be attributed.

Objective

The derivatization of the triazolopyridine molecule has been widely discussed in several scientific articles, focusing on its biological and pharmacological properties. As lead compounds for developing new drugs, many analogues of Triazolopyridine have been found. This article summarizes and discusses the literature surrounding the synthesis and biological evaluation of the triazolopyridine framework.

Methods

Relevant keywords were used to identify relevant published literature from all relevant databases, including SciFinder, PubMed, and Google Scholar. Supplementary relevant literature bibliographies were also searched to locate linked reports.

Results

Step-by-step explanations of the synthetic approaches to Triazolopyridine-based ring systems were found in the literature. All Triazolopyridine derivative's pharmacological activities were enumerated according to their targets, and a detailed structure–activity link was created.

Conclusion

The current review highlights various synthetic techniques for fabricating the triazolopyridine framework and its uses across several medical chemistry fields. The wide range of biological effects of compounds with the triazolopyridine skeleton, including those that are antibacterial, antifungal, anticancer, anti-inflammatory, antitubercular, analgesic, anticancer, and antidepressant, make them crucial in the process of developing new drugs and so on. Despite extensive research, the structure-based drug design technique can create new, effective pharmacophores.

中文翻译：

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三唑并吡啶，合成方法和药理学属性的主旋律：广泛综述

背景

著名的合成药效基团，如 Filgotinib、达哌唑和曲唑酮，都以三唑并吡啶作为其主要构建元素。它在药物化学领域变得更加知名，这可能归因于其广泛的影响。

客观的

三唑并吡啶分子的衍生化已在多篇科学文章中得到广泛讨论，重点关注其生物学和药理学特性。作为开发新药的先导化合物，已经发现了许多三唑并吡啶的类似物。本文总结并讨论了有关三唑并吡啶骨架的合成和生物学评价的文献。

方法

相关关键词用于从所有相关数据库（包括 SciFinder、PubMed 和 Google Scholar）中识别相关已发表文献。还搜索了补充相关文献参考书目以找到链接的报告。

结果

在文献中可以找到对基于三唑并吡啶的环系统的合成方法的逐步解释。根据其靶点列举了所有三唑并吡啶衍生物的药理活性，并创建了详细的结构-活性联系。

结论

当前的综述重点介绍了制造三唑并吡啶框架的各种合成技术及其在多个医学化学领域的用途。具有三唑并吡啶骨架的化合物具有广泛的生物效应，包括抗菌、抗真菌、抗癌、抗炎、抗结核、镇痛、抗癌、抗抑郁等，使其在新药开发等过程中发挥着至关重要的作用。尽管进行了广泛的研究，基于结构的药物设计技术仍然可以创造新的、有效的药效团。