Fluorogenic and Cell-Permeable Rhodamine Dyes for High-Contrast Live-Cell Protein Labeling in Bioimaging and Biosensing,Angewandte Chemie International Edition

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Fluorogenic and Cell-Permeable Rhodamine Dyes for High-Contrast Live-Cell Protein Labeling in Bioimaging and Biosensing
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-07-22 , DOI: 10.1002/anie.202307641
Dongjuan Si ₁ , Quanlin Li ₁ , Yifan Bao ₁ , Jingye Zhang ₁ , Lu Wang ₁

Affiliation

By manipulating the equilibrium between a nonfluorescent spirocyclic state (unbound) and a fluorescent zwitterion state (protein-bound), fluorogenic and cell-permeable rhodamine dyes have been developed for high-contrast protein labeling in living cells. Such new generation of probes offer exceptional performance in multi-color/lifetime imaging, superresolution microscopy, single protein tracking, and chemigenetic biosensors.

中文翻译：

用于生物成像和生物传感中高对比度活细胞蛋白标记的荧光和细胞渗透性罗丹明染料

通过操纵非荧光螺环状态（未结合）和荧光两性离子状态（蛋白质结合）之间的平衡，已开发出荧光和细胞可渗透的罗丹明染料，用于活细胞中的高对比度蛋白质标记。此类新一代探针在多色/寿命成像、超分辨率显微镜、单蛋白追踪和化学遗传生物传感器方面具有卓越的性能。

更新日期：2023-07-22

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