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Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-07-21 , DOI: 10.1021/acsami.3c06139 Tatsiana Mikulchyk 1 , John Walsh 2 , Jacinta Browne 1, 3 , Izabela Naydenova 1 , Dervil Cody 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-07-21 , DOI: 10.1021/acsami.3c06139 Tatsiana Mikulchyk 1 , John Walsh 2 , Jacinta Browne 1, 3 , Izabela Naydenova 1 , Dervil Cody 1
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The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point of maximum acoustic pressure) on the hologram’s response has been investigated for two types of therapeutic ultrasound systems: a sonoporation system and an ultrasound physiotherapy system. Findings show that, above a switching temperature of 45 °C, the ultrasound-induced temperature rise produces a structural change in the hologram, which manifests as a visible color change. The area of the color change region correlates with the ultrasound exposure conditions. The suitability of the hologram as a simple and quick QA test tool for therapeutic ultrasound systems has been demonstrated. A prototype ultrasound testing unit which facilitates user-friendly, reproducible testing of the holograms in a clinical setting is also reported.
中文翻译：
用于超声治疗系统质量保证的变色反射全息图
临床治疗超声设备的声输出需要定期进行质量保证 (QA) 测试，以确保治疗的安全性和有效性，并尽快检测到与预期输出功率密度的任何潜在有害偏差。全息图由丙烯酸酯光聚合物薄膜中制造的反射光栅组成，已开发出可响应入射超声波能量，使重建全息图的颜色从红色变为绿色的立即、可见且永久的变化。已经针对两种类型的治疗超声系统研究了治疗超声声波参数（暴露时间、超声功率密度和接近最大声压点）对全息图响应的影响：声孔系统和超声物理治疗系统。研究结果表明，在 45°C 的切换温度以上，超声波引起的温度升高会导致全息图发生结构变化，表现为可见的颜色变化。颜色变化区域的面积与超声暴露条件相关。全息图作为超声治疗系统简单快速的 QA 测试工具的适用性已得到证明。还报道了一种原型超声测试装置，它有助于在临床环境中对全息图进行用户友好的、可重复的测试。
更新日期：2023-07-21
中文翻译：
用于超声治疗系统质量保证的变色反射全息图
临床治疗超声设备的声输出需要定期进行质量保证 (QA) 测试，以确保治疗的安全性和有效性，并尽快检测到与预期输出功率密度的任何潜在有害偏差。全息图由丙烯酸酯光聚合物薄膜中制造的反射光栅组成，已开发出可响应入射超声波能量，使重建全息图的颜色从红色变为绿色的立即、可见且永久的变化。已经针对两种类型的治疗超声系统研究了治疗超声声波参数（暴露时间、超声功率密度和接近最大声压点）对全息图响应的影响：声孔系统和超声物理治疗系统。研究结果表明，在 45°C 的切换温度以上，超声波引起的温度升高会导致全息图发生结构变化，表现为可见的颜色变化。颜色变化区域的面积与超声暴露条件相关。全息图作为超声治疗系统简单快速的 QA 测试工具的适用性已得到证明。还报道了一种原型超声测试装置，它有助于在临床环境中对全息图进行用户友好的、可重复的测试。
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