Regulation of the ATP-binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood–brain barrier endothelial cells,British Journal of Pharmacology

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Regulation of the ATP-binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood–brain barrier endothelial cells
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2023-07-21 , DOI: 10.1111/bph.16196
Yu Siong Ho ₁ , Pablo Torres-Vergara ₂ , Jeffrey Penny ₁

Affiliation

Blood–brain barrier (BBB) ABCB1, ABCG2 and ABCC5 transporters influence central therapeutic drug distribution. Transporter expression is regulated by the NR3C1, NR1I3 and NR1I2 nuclear receptors, but their precise roles in brain are poorly understood. We investigated the effects of selective ligand-based activation of NR3C1, NR1I3, NR1I2 and NR2B1 in porcine brain endothelial cells (PBECs).

中文翻译：

猪血脑屏障内皮细胞核受体对 ATP 结合盒转运蛋白 ABCB1、ABCG2 和 ABCC5 的调节

血脑屏障 (BBB) ABCB1、ABCG2 和 ABCC5 转运蛋白影响中枢治疗药物的分布。转运蛋白的表达受 NR3C1、NR1I3 和 NR1I2 核受体的调节，但它们在大脑中的确切作用尚不清楚。我们研究了猪脑内皮细胞 (PBEC) 中基于配体的选择性激活 NR3C1、NR1I3、NR1I2 和 NR2B1 的影响。

更新日期：2023-07-21

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