通过自组装结构和疏水核心排列研究基于 AIEgen 的两亲性聚合物的 AIE 行为,Polymer Chemistry

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通过自组装结构和疏水核心排列研究基于 AIEgen 的两亲性聚合物的 AIE 行为
Polymer Chemistry ( IF 4.1 ) Pub Date : 2023-07-21 , DOI: 10.1039/d3py00559c
Liang Wang ₁ , Ghada E. Khedr ₂ , Lei Luo ₁ , Shiling Zhang ₁ , Zhiying Li ₁ , Shanmeng Lin ₁ , Jinyan Luo ₁ , Qi Xing ₁ , Jin Geng ₁

Affiliation

纳米级聚合物囊泡表现出显着的聚集诱导发射（AIE）效应，在生物医学应用中具有巨大的潜力。在这项研究中，利用可逆加成断裂链转移自缩合乙烯基聚合合成了三种类型的两亲聚合物。这些聚合物具有直链、支链和星形结构，由疏水和亲水单元组成，即(2-(4-乙烯基苯基)乙烯-1,1,2-三基)三苯(TPEE)和N , N-分别是二甲基丙烯酰胺（DMA）。我们发现当 TPEE 和 DMA 的比例为 3 : 1 ( n / n），由于星状聚合物的分子间自组装产生的聚合物囊泡中 TPEE 的聚集更紧密，因此星状聚合物表现出明显强于线性和支化聚合物的发射。然而，当亲水链长度缩短时，星形聚合物的 AIE 行为弱于线性聚合物，这可能是由于在线性聚合物内胶束转变为囊泡过程中 TPEE 具有更大的空间位阻。我们还采用星状聚合物衍生的纳米颗粒对两种类型的细胞（A549 和 HepG2）进行活细胞成像。这项研究为设计 AIE 聚合物结构以实现更好的发射行为提供了重要的见解。

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Investigating AIE behaviors of amphiphilic AIEgen-based polymers through self-assembly architectures and hydrophobic core arrangements

Nanoscale polymersomes showing a prominent aggregation-induced emission (AIE) effect have enormous potential in biomedical applications. In this study, three types of amphiphilic polymers were synthesized using reversible addition–fragmentation chain transfer self-condensing vinyl polymerization. These polymers had linear, branched, and star-like structures, and were composed of hydrophobic and hydrophilic units, namely (2-(4-vinylphenyl)ethene-1,1,2-triyl)tribenzene (TPEE) and N,N-dimethylacrylamide (DMA), respectively. We found that when the ratio of TPEE and DMA was 3 : 1 (n/n), the star-like polymers showed significantly stronger emission than linear and branched polymers, due to tighter aggregation of TPEE in the polymersomes derived from intermolecular self-assembly of the star-like polymers. However, when the hydrophilic chain length was shortened, the AIE behavior of the star-like polymers was weaker than that of the linear polymers, possibly due to greater steric hindrance of TPEE during the transformation of micelles to vesicles within the linear polymers. We also employed the star-like polymer-derived nanoparticles for living cell imaging with two types of cells (A549 and HepG2). This study offers considerable insights into designing an AIE polymer structure for better emission behaviors.

更新日期：2023-07-21

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