<br>SLIM 技巧：平面离子导向开发的工具、概念和策略,Journal of the American Society for Mass Spectrometry

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SLIM 技巧：平面离子导向开发的工具、概念和策略
Journal of the American Society for Mass Spectrometry ( IF 3.1 ) Pub Date : 2023-07-20 , DOI: 10.1021/jasms.3c00163
Cullen Greer ₁ , Zackary Kinlein ₁ , Brian H Clowers ₁

Affiliation

使用平面电极结构（例如，无损离子操纵结构，TW-SLIM）的行波离子淌度实验利用了印刷电路板（PCB）的成熟制造能力。由于常规机械精度水平低于 150 μm，PCB 用作平面离子导向器所提供的概念灵活性非常广泛。迄今为止，TW-SLIM 平台的设计和构建需要大量的传统专业知识，特别是在模拟和电路布局策略方面。为了降低 TW-SLIM 实施的障碍，我们引入了基于 Python 的交互式工具，可帮助以最少的用户输入对平面离子导向器的核心电极足迹进行图形布局。这些脚本还导出准确的组件位置和分配，以便直接集成到 KiCad 和 SIMION 中，以进行 PCB 最终确定和离子飞行模拟。包含SLIM Pickins （PCB CAD 生成）和Pigsim （SIMION 工作区生成）的脚本集所体现的设计概念借鉴了 WSU 运行的研究级 TW-SLIM 平台独立开发的经验教训。由于 PCB 制造工艺固有的灵活性以及制造前用于电路板布局的时间，这两个脚本都有助于实现快速、迭代的设计考虑。由于只需要几个预定义参数（即 TW-SLIM 单体宽度、TW 转弯后的 x 位置和 TW 转弯后的 y 位置），因此可以通过以下方式设计精确的组件布局和随附的模拟空间：分钟。脚本的电路板布局能力没有已知的限制，设计布局的尺寸最终受到最终 PCB 设计和仿真工具 KiCad 和 SIMION 的能力的限制，以容纳构成最终设计的数千个电极（即 RAM 和软件开销）。为了消除探索新 SLIM 轨道的障碍以及需要大量修改和工程时间的布局错误的可能性， SLIM Pickins和Pigsim工具（作为支持信息包含在内）允许用户快速设计一定长度的平面离子导向器，模拟其能够限制和传输离子，将假设的电路板轮廓与给定的真空室尺寸进行比较，并生成接近生产就绪的 PCB CAD 文件。除了这些工具之外，本报告还概述了一系列关于使用平面离子导向器进行 TW 离子淌度实验的真空馈通和真空室设计的成本节约策略。

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SLIM Tricks: Tools, Concepts, and Strategies for the Development of Planar Ion Guides

Traveling wave ion mobility experiments using planar electrode structures (e.g., structures for lossless ion manipulation, TW-SLIM) leverage the mature manufacturing capabilities of printed circuit boards (PCBs). With routine levels of mechanical precision below 150 μm, the conceptual flexibility afforded by PCBs for use as planar ion guides is expansive. To date, the design and construction of TW-SLIM platforms require considerable legacy expertise, especially with respect to simulation and circuit layout strategies. To lower the barrier of TW-SLIM implementation, we introduce Python-based interactive tools that assist in graphical layout of the core electrode footprints for planar ion guides with minimal user inputs. These scripts also export the exact component locations and assignments for direct integration into KiCad and SIMION for PCB finalization and ion flight simulations. The design concepts embodied in the set of scripts comprising SLIM Pickins (PCB CAD generation) and pigsim (SIMION workspace generation) build upon the lessons learned in the independent development of the research-grade TW-SLIM platforms in operation at WSU. Due to the inherent flexibility of the PCB manufacturing process and the time devoted to board layouts prior to manufacturing, both scripts serve to enable rapid, iterative design considerations. Because only a few predefined parameters are necessary (i.e., the TW-SLIM monomer width, x position following a TW Turn, and y position following a TW Turn) it is possible to design the exact component layouts and accompanying simulation space in a manner of minutes. There is no known limitation to the board layout capacities of the scripts, and the size of a designed layout is ultimately constrained by the abilities of the final PCB design and simulation tools, KiCad and SIMION, to accommodate the thousands of electrodes comprising the final design (i.e., RAM and software overhead). Toward removing the barriers to exploring new SLIM tracks and the likelihood of layout errors that require considerable revision and engineering time, the SLIM Pickins and pigsim tools (included as Supporting Information) allow the user to quickly design a length of planar ion guide, simulate its abilities to confine and transmit ions, compare hypothetical board outlines to given vacuum chamber dimensions, and generate a near-production ready PCB CAD file. In addition to these tools, this report outlines a series of cost-saving strategies with respect to vacuum feedthroughs and vacuum chamber design for TW ion mobility experiments using planar ion guides.

更新日期：2023-07-20

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