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Chiral Sulfur Nanosheets for Dual-Selective Inhibition of Gram-Positive Bacteria
ACS Nano ( IF 15.8 ) Pub Date : 2023-07-19 , DOI: 10.1021/acsnano.3c03458 Xiang Huang 1 , Chenxin Lu 1 , Wenjie Zhang 1 , Lulu Liu 1 , Zhengbao Zha 1 , Zhaohua Miao 1
ACS Nano ( IF 15.8 ) Pub Date : 2023-07-19 , DOI: 10.1021/acsnano.3c03458 Xiang Huang 1 , Chenxin Lu 1 , Wenjie Zhang 1 , Lulu Liu 1 , Zhengbao Zha 1 , Zhaohua Miao 1
Affiliation
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Elemental sulfur is the oldest known antimicrobial agent. However, conventional sulfur in the clinic suffers from poor aqueous solubility and limited antibacterial activity, greatly hindering its practical use. Herein, we report a reform strategy coupling dimension engineering with chirality transfer to convert conventional 3D sulfur particles into chiral 2D sulfur nanosheets (S-NSs), which exhibit 50-fold improvement of antibacterial capability and dual-selective inhibition against Gram-positive bacteria. Benefiting from the inherent selectivity of S-NSs and chirality selectivity from decorated d-histidine, the obtained chiral S-NSs are proven to precisely kill Gram-positive drug-resistant bacteria, while no obvious bacterial inhibition is observed for Gram-negative bacteria. Mechanism studies reveal that S-NSs produce numerous reactive oxygen specipoes and hydrogen sulfide after incubation with bacteria, thus causing bacterial membrane destruction, respiratory chain damage, and ATP production inhibition. Upon spraying chiral S-NSs dispersions onto MRSA-infected wounds, the skin healing process was greatly accelerated in 8 days due to metabolism inhibition and oxidative damage of bacteria, indicating the excellent treatment efficiency of MRSA-infected wounds. This work converts the traditional well-known sulfur into modern antibacterial agents with a superior Gram-selectivity bactericidal capability.
中文翻译：
用于双重选择性抑制革兰氏阳性细菌的手性硫纳米片
元素硫是已知最古老的抗菌剂。然而临床上常规硫磺的水溶性差、抗菌活性有限，极大地阻碍了其实际应用。在此，我们报告了一种将尺寸工程与手性转移相结合的改革策略，将传统的3D硫颗粒转化为手性2D硫纳米片（S-NSs），其抗菌能力提高了50倍，并对革兰氏阳性菌具有双重选择性抑制作用。得益于S-NSs固有的选择性和修饰后的d-组氨酸的手性选择性，所获得的手性S-NSs被证明能够精确杀灭革兰氏阳性耐药菌，而对革兰氏阴性菌没有观察到明显的细菌抑制作用。机理研究表明，S-NSs与细菌孵育后会产生大量活性氧和硫化氢，从而导致细菌膜破坏、呼吸链损伤和ATP产生抑制。将手性S-NSs分散体喷洒在MRSA感染的伤口上后，由于细菌的代谢抑制和氧化损伤，皮肤愈合过程在8天内大大加速，表明对MRSA感染的伤口具有优异的治疗效果。这项工作将传统众所周知的硫转化为具有卓越革兰氏选择性杀菌能力的现代抗菌剂。
更新日期：2023-07-19
中文翻译：
用于双重选择性抑制革兰氏阳性细菌的手性硫纳米片
元素硫是已知最古老的抗菌剂。然而临床上常规硫磺的水溶性差、抗菌活性有限，极大地阻碍了其实际应用。在此，我们报告了一种将尺寸工程与手性转移相结合的改革策略，将传统的3D硫颗粒转化为手性2D硫纳米片（S-NSs），其抗菌能力提高了50倍，并对革兰氏阳性菌具有双重选择性抑制作用。得益于S-NSs固有的选择性和修饰后的d-组氨酸的手性选择性，所获得的手性S-NSs被证明能够精确杀灭革兰氏阳性耐药菌，而对革兰氏阴性菌没有观察到明显的细菌抑制作用。机理研究表明，S-NSs与细菌孵育后会产生大量活性氧和硫化氢，从而导致细菌膜破坏、呼吸链损伤和ATP产生抑制。将手性S-NSs分散体喷洒在MRSA感染的伤口上后，由于细菌的代谢抑制和氧化损伤，皮肤愈合过程在8天内大大加速，表明对MRSA感染的伤口具有优异的治疗效果。这项工作将传统众所周知的硫转化为具有卓越革兰氏选择性杀菌能力的现代抗菌剂。
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