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Mussel-Derived Bioadaptive Artificial Tendon Facilitates the Cell Proliferation and Tenogenesis to Promote Tendon Functional Reconstruction
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-07-18 , DOI: 10.1002/adhm.202203400
Xiaoyan Wang 1, 2 , Kaige Xu 1, 3 , Lan Mu 1 , Xiaoqi Zhang 4 , Guangtao Huang 1 , Malcolm Xing 3 , Zhibin Li 1 , Jun Wu 1
Affiliation  

Tendon injuries range from acute-related trauma to chronic-related injuries are prevalent and bring substantial pain, functional loss, and even disability to the patients. The management of tendon injuries is tricky due to the innate limited regenerative capability of the tendon. Currently, surgical intervention of tendon injuries with artificial tendons remains the standard of care. However, most of artificial tendons are manufactured with synthetic materials, which possess relatively poor biomimetic characteristics and inadequate inherent biodegradability, hence rendering limited cell proliferation and migration for tendon healing. To address these limitations, this work develops a mussel-derived artificial tendon based on double-cross-linked chitosan modification. In this design, decellularized artificial tendon serves as a natural biomimetic scaffold to facilitate the migration and adhesion of tendon repair cells. Additionally, as the cells proliferate, the artificial tendon can be degraded to facilitate tendon regeneration. Moreover, the chitosan cross-linking further enhances the mechanical strength of artificial tendon and offers a controllable degradation. The in vitro and in vivo experimental results demonstrate that mussel-derived artificial tendon not only accelerate the tendon functional reconstruction but also enable harmless clearance at postimplantation. The finding provides a promising alternative to conventional artificial tendons and spurs a new frontier to explore nature-derived artificial tendons.

中文翻译:

贻贝生物适应性人工肌腱促进细胞增殖和肌腱形成,促进肌腱功能重建

肌腱损伤的范围从急性相关损伤到慢性相关损伤都很普遍,给患者带来严重的疼痛、功能丧失甚至残疾。由于肌腱固有的有限再生能力,肌腱损伤的治疗非常棘手。目前,使用人工肌腱进行肌腱损伤的手术干预仍然是标准治疗方法。然而,大多数人工肌腱都是由合成材料制成,其仿生特性相对较差,固有的生物降解性不足,因此导致肌腱愈合的细胞增殖和迁移受到限制。为了解决这些限制,这项工作开发了一种基于双交联壳聚糖修饰的贻贝人工肌腱。在该设计中,脱细胞人工肌腱作为天然仿生支架,促进肌腱修复细胞的迁移和粘附。此外,随着细胞增殖,人工肌腱可以降解以促进肌腱再生。此外,壳聚糖交联进一步增强了人工肌腱的机械强度并提供了可控的降解。体外和体内实验结果表明,贻贝人工肌腱不仅加速肌腱功能重建,而且能够在植入后实现无害清除。这一发现为传统人工肌腱提供了一种有前途的替代品,并激发了探索自然人工肌腱的新领域。
更新日期:2023-07-18
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