Arginine Methylation Regulates Self-Assembly of Peptides,Macromolecular Rapid Communications

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Arginine Methylation Regulates Self-Assembly of Peptides
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2023-07-18 , DOI: 10.1002/marc.202300308
Jinyan Song ₁ , Xiaowei Mo ₁ , Xin Liu ₁ , Binbin Hu ₁ , Zeyu Zhang ₁ , Zhilin Yu ₁

Affiliation

Bio-inspired design of peptides represents one facile strategy for development of supramolecular monomers for self-assembly into well-defined nanostructures. Inspired by methylation of arginine during post-translational modification for manipulating protein functions, herein, the controllable self-assembly of peptides via rational incorporation of methylated arginine residues into bola-amphiphilic peptides is reported. A series of bola-amphiphilic peptides are designed and synthesized either containing natural arginine or methylated arginine and investigate the influence of arginine methylation on peptide assembly. This study finds that incorporation of symmetrically di-methylated arginine into oppositely charged hexapeptide hex-SDMAE leads to distinct assembling performance compare to natural peptide hex-RE. The findings demonstrate that the methylation of rationally designed peptide sequences allows for regulation of self-assembly of peptides, thus implying the great potential of arginine methylation in establishing controllable peptide assembling systems and creating in situ formulation of biomedical materials in the future.

中文翻译：

精氨酸甲基化调节肽的自组装

肽的仿生设计代表了一种开发超分子单体的简单策略，用于自组装成明确的纳米结构。受用于操纵蛋白质功能的翻译后修饰过程中精氨酸甲基化的启发，本文报道了通过将甲基化精氨酸残基合理掺入 bola 两亲性肽来实现肽的可控自组装。设计并合成了一系列含有天然精氨酸或甲基化精氨酸的bola-两亲性肽，并研究了精氨酸甲基化对肽组装的影响。这项研究发现，与天然肽 hex-RE 相比，将对称二甲基化精氨酸掺入带相反电荷的六肽 hex-SDMAE 会产生不同的组装性能。研究结果表明，合理设计的肽序列的甲基化可以调节肽的自组装，这意味着精氨酸甲基化在未来建立可控的肽组装系统和创建生物医学材料的原位制剂方面具有巨大的潜力。

更新日期：2023-07-18

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