Diabetic wound treatment poses significant global challenges in clinical work and research, alternative treatment approaches need to be developed urgently. Exudate management and angiogenic function are critical to improve diabetic wound healing. In this work, a Janus bilayer electrospun dressing is fabricated via modified electrospinning technologies. The outer layer of dressing is hydrophilic deferoxamine (DFO)-loaded polycaprolactone (PCL) and polyethylene glycol (PEG) random nanofiber, while the inner layer is hydrophobic PCL nanofiber with mesh-like structure and patterns, and the bilayer layers are fabricated via layer-by-layer assembly. The mechanical properties, wettability, and drug release performance of the Janus dressing were studied. Difference in wettability between the two layers enables excess biological fluid to drain away from the wound, and simultaneously trigger the cascade release of DFO in the outer layer. The in vitro data evidenced that the Janus dressing had good biocompatibility. The mesh-like inner surface is considered favorable for attachment and proliferation of fibroblast, and the controlled release of DFO significantly enhanced tube formation. In vivo results from a diabetic full-thickness cutaneous wound model showed that the Janus dressing created a unique microenvironment that accelerates the wound healing process through effective biofluid draining and stimulation of angiogenesis process. The findings indicated that the Janus dressing presented a potentially valuable method for the management and treatment of diabetic wound in clinical applications.

糖尿病伤口治疗对临床工作和研究提出了重大的全球挑战，迫切需要开发替代治疗方法。渗出液管理和血管生成功能对于改善糖尿病伤口愈合至关重要。在这项工作中，Janus 双层电纺敷料是通过改进的静电纺丝技术制造的。敷料外层为亲水性负载去铁胺（DFO）的聚己内酯（PCL）和聚乙二醇（PEG）无规纳米纤维，内层为具有网状结构和图案的疏水性PCL纳米纤维，双层层通过层压法制备逐层组装。研究了 Janus 敷料的机械性能、润湿性和药物释放性能。两层之间的润湿性差异使多余的生物液体能够从伤口排出，同时触发外层DFO的级联释放。这体外数据证明Janus敷料具有良好的生物相容性。网状内表面被认为有利于成纤维细胞的附着和增殖，并且 DFO 的受控释放显着增强了管的形成。糖尿病全层皮肤伤口模型的体内结果表明，Janus 敷料创造了独特的微环境，通过有效的生物液体引流和刺激血管生成过程来加速伤口愈合过程。研究结果表明，Janus 敷料为临床应用中糖尿病伤口的管理和治疗提供了一种潜在有价值的方法。