Drug Delivery and Translational Research ( IF 5.7 ) Pub Date : 2023-07-15 , DOI: 10.1007/s13346-023-01391-y Giulia Pitzanti 1 , Valentyn Mohylyuk 2 , Francesca Corduas 1, 3 , Niall M Byrne 1 , Jonathan A Coulter 1 , Dimitrios A Lamprou 1
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Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate photocurable resins based on urethane dimethacrylate (UDMA) combined with three different difunctional methacrylic diluents named ethylene glycol dimethacrylate (EGDMA), di(ethylene glycol) dimethacrylate (DEGDMA) or tri(ethylene glycol) dimethacrylate (TEGDMA). The resins were tested for viscosity, thermal behaviour and printability. After printing, the 3D printed specimens were measured with a digital calliper in order to investigate their accuracy to the digital model and tested with FT-IR, TGA and DSC. Their mechanical properties, contact angle, water sorption and biocompatibility were also evaluated. The photopolymerizable formulations investigated in this work achieved promising properties so as to be suitable for tissue engineering and other biomedical applications.
Graphical abstract
中文翻译：
用于立体光刻 3D 打印的聚氨酯二甲基丙烯酸酯基光聚合树脂：物理化学表征和生物相容性评估
还原光聚合（VP）三维打印（3DP）在电子、制药、生物医学设备和组织工程等许多不同领域引起了极大的关注。由于生物相容性光固化树脂的可用性较低，其在医疗保健领域的应用仍然受到限制。在这项工作中，我们配制了基于聚氨酯二甲基丙烯酸酯（UDMA）与三种不同的双官能甲基丙烯酸稀释剂（即乙二醇二甲基丙烯酸酯（EGDMA）、二（乙二醇）二甲基丙烯酸酯（DEGDMA）或三（乙二醇）二甲基丙烯酸酯（TEGDMA））的光固化树脂。对树脂的粘度、热性能和适印性进行了测试。打印后，使用数字卡尺测量 3D 打印的样本，以研究其对数字模型的准确性，并使用 FT-IR、TGA 和 DSC 进行测试。还评估了它们的机械性能、接触角、吸水性和生物相容性。这项工作中研究的光聚合配方实现了有前景的特性，从而适用于组织工程和其他生物医学应用。
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