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Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2023-07-13 , DOI: 10.1021/acs.oprd.3c00106 Zhiquan Chen 1 , Jian Liu 1 , Lei Ni 1 , Juncheng Jiang 1, 2 , Yuan Yu 1, 2 , Yong Pan 1, 2
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2023-07-13 , DOI: 10.1021/acs.oprd.3c00106 Zhiquan Chen 1 , Jian Liu 1 , Lei Ni 1 , Juncheng Jiang 1, 2 , Yuan Yu 1, 2 , Yong Pan 1, 2
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The traditional batch production process for methyl sulfone (MSM) from dimethyl sulfoxide (DMSO) is highly exothermic and poses serious safety risks. In this work, we present a continuous-flow synthesis strategy using microchannel reactors to enhance the safety and efficiency of industrial-scale MSM production. Four specifications of microchannel reactors have been constructed and then were applied for the continuous-flow synthesis of MSM with both high yield and purity. The effects of the channel diameter, water bath temperature, catalytic dosage, residence time, and segmented temperature control on MSM yield were systematically investigated. By gradually optimizing the design parameters, the yield of MSM in the industrialized microchannel reactor reached 95.3%, and the average annual time yield of MSM was 18.36 t·a–1. In addition, the maximum overlimit temperature in the continuous flow does not exceed 10 °C, and the overtemperature time is less than 20 s. Dual temperature-controlled continuous-flow process was more beneficial to increase the yield of MSM. The microchannel continuous-flow amplification process can greatly improve the productivity of MSM while ensuring the high yield of MSM, which is a promising strategy for the efficient and safe production of MSM at an industrial scale.
中文翻译：
使用微通道反应器连续流合成甲基砜：一种更安全、更高效的生产策略
传统的以二甲基亚砜（DMSO）为原料批量生产二甲砜（MSM）的工艺过程放热剧烈，存在严重的安全风险。在这项工作中，我们提出了一种使用微通道反应器的连续流合成策略，以提高工业规模 MSM 生产的安全性和效率。搭建了四种规格的微通道反应器，用于连续流合成高产率和高纯度的MSM。系统研究了通道直径、水浴温度、催化剂用量、停留时间和分段温度控制对MSM产率的影响。通过逐步优化设计参数，工业化微通道反应器中MSM收率达到95.3%，MSM年均产量18.36 t·a –1。另外，连续流中最高超限温度不超过10℃，超温时间小于20s。双温控连续流工艺更有利于提高MSM的产率。微通道连续流扩增工艺可以在保证MSM高产率的同时极大地提高MSM的生产率，是工业规模高效、安全生产MSM的一种有前景的策略。
更新日期：2023-07-14
中文翻译：
使用微通道反应器连续流合成甲基砜：一种更安全、更高效的生产策略
传统的以二甲基亚砜（DMSO）为原料批量生产二甲砜（MSM）的工艺过程放热剧烈，存在严重的安全风险。在这项工作中，我们提出了一种使用微通道反应器的连续流合成策略，以提高工业规模 MSM 生产的安全性和效率。搭建了四种规格的微通道反应器，用于连续流合成高产率和高纯度的MSM。系统研究了通道直径、水浴温度、催化剂用量、停留时间和分段温度控制对MSM产率的影响。通过逐步优化设计参数，工业化微通道反应器中MSM收率达到95.3%，MSM年均产量18.36 t·a –1。另外，连续流中最高超限温度不超过10℃，超温时间小于20s。双温控连续流工艺更有利于提高MSM的产率。微通道连续流扩增工艺可以在保证MSM高产率的同时极大地提高MSM的生产率，是工业规模高效、安全生产MSM的一种有前景的策略。
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