Detection of the Synthetic Coolant Menthone 1,2-Glycerol Ketal in an e-Liquid and in Electronic Waterpipe Aerosols Therefrom,Chemical Research in Toxicology

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Detection of the Synthetic Coolant Menthone 1,2-Glycerol Ketal in an e-Liquid and in Electronic Waterpipe Aerosols Therefrom
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2023-07-13 , DOI: 10.1021/acs.chemrestox.3c00089
Theodore P Klupinski ₁ , Erich D Strozier ₁ , David D Koebel ₁ , Eric A Lucas ₁

Affiliation

The presence and toxicological risks of synthetic coolants in electronic nicotine delivery systems (ENDS) have not been thoroughly studied. We identified the synthetic coolant menthone 1,2-glycerol ketal (MGK) in a menthol-flavored e-liquid at a concentration of ∼170 μg/mL. We also detected MGK in aerosols resulting from heating the e-liquid with an electronic waterpipe. MGK was initially detected in the e-liquid by two-dimensional gas chromatography–time-of-flight mass spectrometry. To avoid potential analytical artifacts that could result from heating samples in the injection port of the gas chromatograph, quantitation of MGK in the e-liquid was accomplished using a liquid chromatography–tandem mass spectrometry method. Following recent reports identifying other synthetic coolants in e-liquids, these results add knowledge about inhalation exposures from ENDS use and suggest the importance of future research to study the potential inhalation toxicity related to the use of MGK-containing e-liquids in ENDS devices. Furthermore, the results demonstrate the ability to quantify ketals in e-liquids using liquid chromatography methods.

中文翻译：

电子烟液及其电子水烟气溶胶中合成冷却剂薄荷酮 1,2-甘油缩酮的检测

电子尼古丁输送系统 (ENDS) 中合成冷却剂的存在及其毒理学风险尚未得到彻底研究。我们在薄荷味电子烟液中发现了浓度为 ∼170 μg/mL 的合成清凉剂薄荷酮 1,2-甘油缩酮 (MGK)。我们还在用电子水管加热电子烟液产生的气溶胶中检测到了 MGK。 MGK 最初是通过二维气相色谱-飞行时间质谱法在电子烟液中检测到的。为了避免在气相色谱仪进样口加热样品可能导致潜在的分析伪影，使用液相色谱-串联质谱法完成了电子烟液中 MGK 的定量。继最近的报告确定了电子烟液中的其他合成冷却剂之后，这些结果增加了有关 ENDS 使用中吸入暴露的知识，并表明未来研究与在 ENDS 设备中使用含有 MGK 的电子烟液相关的潜在吸入毒性的重要性。此外，结果证明了使用液相色谱方法量化电子液体中缩酮的能力。

更新日期：2023-07-13

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