大孔介孔二氧化硅：模板设计、薄膜制备和生物分子渗透,Materials Chemistry Frontiers

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大孔介孔二氧化硅：模板设计、薄膜制备和生物分子渗透
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2023-07-13 , DOI: 10.1039/d3qm00378g
Sebastián Alberti ₁ , Sonja Schmidt ₂ , Simone Hageneder ₃ , Paula C. Angelomé ₄ , Galo J. A. A. Soler-lllia ₅ , Philipp Vana ₂ , Jakub Dostalek _{3,

6} , Omar Azzaroni ₁ , Wolfgang Knoll _{3,

7}

Affiliation

纳米孔已应用于人工生物催化系统、受控药物输送和固态传感装置的开发。生物大分子与表面的相互作用显示出对纳米孔径的依赖性，这对于它们渗透多孔材料的能力至关重要。在这种情况下，通过蒸发诱导自组装获得的有序介孔材料是测试孔与生物分子相互作用的模型材料。然而，这些材料的孔径通常限制在2-10 nm范围内，因此，作为模板剂的新型聚合物有可能为孔径大于10 nm的介孔二氧化硅薄膜（MTF）的合成提供一种简单、可重复的途径。无需使用溶胀剂或额外的结构化剂。这里，我们通过将超分子模板和相分离与定制的嵌段共聚物相结合，提出了一种新颖而简单的大孔 MTF 方法。通过简单的可逆加成-断裂链转移 (RAFT) 聚合方法控制用作模板的亲水聚合物嵌段的长度和性质，可以精确调节氧化物孔径分布（小中孔直径在 13-18 nm 之间）。通过展示这些新材料提供的生物分子渗透能力，以使用 pluronic F127 作为模板制备的广泛 MTF 为基准，突出了这些特征的重要性。简要测试并讨论了蛋白质与孔径比、蛋白质位置的影响以及 pH 和离子强度的影响。

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Large-pore mesoporous silica: template design, thin film preparation and biomolecule infiltration

Nanopores have been applied in the development of artificial biocatalytic systems, controlled drug delivery, and solid-state sensing devices. The interaction of biomacromolecules with surfaces show a dependence on the nanopore diameter, crucial in their ability to infiltrate porous materials. In this context, ordered mesoporous materials obtained by evaporation-induced self-assembly are model materials to test pore-biomolecule interactions. Nevertheless, these materials are generally restricted to pore diameters within the 2–10 nm range, therefore, new polymers as templating agents hold potential to provide an easy reproducible route for the synthesis of mesoporous silica thin films (MTF) with pore diameters above 10 nm without the use of swelling or additional structuring agents. Here, we present a novel and simple approach towards large pore MTF through the combination of supramolecular templating and phase separation with tailor-made block co-polymers. Accurate tuning of the oxide pore size distribution (with small mesopores between 13–18 nm diameter) is achieved by controlling the length and the nature of the hydrophilic polymer block used as a template through a simple reversible addition-fragmentation chain transfer (RAFT) polymerization approach. The importance of these features is highlighted by showing the capability that these new materials offer for biomolecule infiltration benchmarked against the widespread MTF prepared using pluronic F127 as a template. Effect of protein to pore diameter ratio, protein location and effect of pH and ionic strength is briefly tested and discussed.

更新日期：2023-07-13

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