Recent Advances in Engineering Bioinks for 3D Bioprinting,Advanced Engineering Materials

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Recent Advances in Engineering Bioinks for 3D Bioprinting
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2023-07-11 , DOI: 10.1002/adem.202300648
Haonan Wang ₁ , Shihao Bi ₂ , Bingbing Shi ₃ , Junchi Ma ₄ , Xiangwei Lv ₃ , Jianfeng Qiu _{4,

5} , Yunyun Wei _{1,

4}

Affiliation

The 3D bioprinting can controllably deposit bioink containing cells and fabricate complex bionic tissue structures in a fast and scalable way, which is expected to completely change the scenario of clinical organ transplantation. Bioprinting holds broad application prospect in tissue engineering, life sciences, and clinical medicine. In the process of 3D bioprinting, bioink, as the carrier of cells and bioactive substances, influences cell activity and accuracy of organ structure after printing. To better understand and design bioink, in this review, the concept, development, and basic composition of bioink are introduced, while focusing on the advantages and disadvantages of various biomaterials, and the use of common cells and biomolecules that constitute bioink. In addition, the properties and applications of various stimuli-responsive smart materials for 4D bioprinting are mentioned. The challenges and development trends of bioink are also summarized.

中文翻译：

用于 3D 生物打印的工程生物墨水的最新进展

3D生物打印可以可控地沉积含有细胞的生物墨水，并以快速、可扩展的方式制造复杂的仿生组织结构，这有望彻底改变临床器官移植的场景。生物打印在组织工程、生命科学、临床医学等领域具有广阔的应用前景。在生物3D打印过程中，生物墨水作为细胞和生物活性物质的载体，影响打印后的细胞活性和器官结构的准确性。为了更好地理解和设计生物墨水，本文介绍了生物墨水的概念、发展和基本组成，同时重点介绍了各种生物材料的优缺点，以及构成生物墨水的常见细胞和生物分子的使用。此外，介绍了用于4D生物打印的各种刺激响应智能材料的特性和应用。还总结了生物墨水的挑战和发展趋势。

更新日期：2023-07-11

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