Organic electronics can be biocompatible and conformable, enhancing the ability to interface with tissue. However, the limitations of speed and integration have, thus far, necessitated reliance on silicon-based technologies for advanced processing, data transmission and device powering. Here we create a stand-alone, conformable, fully organic bioelectronic device capable of realizing these functions. This device, vertical internal ion-gated organic electrochemical transistor (vIGT), is based on a transistor architecture that incorporates a vertical channel and a miniaturized hydration access conduit to enable megahertz-signal-range operation within densely packed integrated arrays in the absence of crosstalk. These transistors demonstrated long-term stability in physiologic media, and were used to generate high-performance integrated circuits. We leveraged the high-speed and low-voltage operation of vertical internal ion-gated organic electrochemical transistors to develop alternating-current-powered conformable circuitry to acquire and wirelessly communicate signals. The resultant stand-alone device was implanted in freely moving rodents to acquire, process and transmit neurophysiologic brain signals. Such fully organic devices have the potential to expand the utility and accessibility of bioelectronics to a wide range of clinical and societal applications.

有机电子器件可以具有生物相容性和舒适性，从而增强与组织交互的能力。然而，迄今为止，速度和集成度的限制使得必须依赖硅基技术来进行高级处理、数据传输和设备供电。在这里，我们创造了一种独立的、舒适的、完全有机的生物电子器件，能够实现这些功能。该器件是垂直内部离子门控有机电化学晶体管 (vIGT)，基于晶体管架构，该架构包含垂直通道和小型化水合通道，可在密集集成阵列内实现兆赫信号范围操作，且无串扰。这些晶体管在生理介质中表现出长期稳定性，并用于生成高性能集成电路。我们利用垂直内部离子门控有机电化学晶体管的高速和低压运行来开发交流电供电的一致性电路来采集和无线通信信号。由此产生的独立装置被植入自由活动的啮齿动物体内，以获取、处理和传输神经生理学大脑信号。这种完全有机的设备有潜力将生物电子学的实用性和可及性扩展到广泛的临床和社会应用。